Scientific Aspects of Carcinogenic Risk Assessment

SCIENTIFIC ASPECTS OF CARCINOGENIC RISK ASSESSMENT 51 TABLE 3.1. Induction of Liver Cancer in BDIII Rats by 4-DAB... 

As this example with p-dichlorobenzene shows the different levels of OELs are connected to differing scientific opinions on the harmful effects of the substance. The selection of what data to review obviously is important for the outcome of the risk assessment. It can also be concluded to not only being dependent on the time-related availability of the data. The potential for a selection bias of what literature to review in risk assessments has been shown by Ruden for the risk assessments concerning the carcinogenic properties of trichloroethylene (Ruden 2001). Although a case-study of acryl amide (Ruden 2004) shows that a selection bias by no means is an inevitable consequence. Another aspect of which the conclusions from a risk... 

The first section of this chapter provides a discussion of hazard assessment, classification of potentially dangerous substances, and the process of risk assessment. A summary of the mandatory and voluntary initiatives for regulating chemicals and biocides in the United States and Europe is also included together with information on the regulatory aspects of hazard communication. The second section deals with the scientific aspects of hazard identification and risk assessment of carcinogenic chemicals within the regulatory context. 

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