Molecular scaffolds

Effect of Hard Core Scaffolds - Molecular "Boojums"... 

AQ2 Table 2 Examples of Polymer uses for Scaffold Molecular Imprinting... 

Salvay, D.M., Shea, L.D., 2006. Inductive tissue engineering with protein and DNA-releasing scaffolds. Molecular Biosystems 2, 36 8. 

The BZ stmcture also has provided a molecular scaffold for a number of peptide receptor ligands (26). Antagonists for the cholecystokinin (CCK-A) receptor, eg, devazepide (65), the thyrotropin-releasing hormone (TRH) receptor, eg, midazolam (66), and the /i -opiate receptor, eg, tifluadom (67), as well as a series of ras famyl transferase inhibitors, eg, BZA-2B (68) (30) have been identified (Table 4). 

EMPl, selected by phage display from random peptide libraries, demonstrates that a dimer of a 20-residue peptide can mimic the function of a monomeric 166-residue protein. In contrast to the minimized Z domain, this selected peptide shares neither the sequence nor the structure of the natural hormone. Thus, there can be a number of ways to solve a molecular recognition problem, and combinatorial methods such as phage display allow us to sort through a multitude of structural scaffolds to discover novel solutions. 

The same kind of results were obtained using the ionic hquid [bmim] [PFg ] as the medium to carry out the reaction in the presence of TEA at 60 °C for 30 s under microwave irradiation [151,152]. Toluene can be also used as the solvent as well TEA as the acid [153]. Heating at 60 °C for a longer period also allowed the reaction of different ketones, thus increasing the potential of the reaction for the generation of molecular diversity around a tricycUc scaffold such as 236 in Scheme 87. 

Diederich F, Gobbi L (1999) Cyclic and Linear Acetylenic Molecular Scaffolding. 201 43-79... 

Keywords Acetylene chemistry. Cross-coupling reactions, Cyclo[n]carbons, Expanded radialenes. Molecular scaffolding. Nanostructures, Perethynylated chromophores, Poly(triacetylene), Tetraethynylethene. 

This article summarizes efforts undertaken towards the synthesis of the cyclo[ ]carbons, the first molecular carbon allotropes for which a rational preparative access has been worked out. Subsequently, a diversity of perethynylated molecules will be reviewed together, they compose a large molecular construction kit for acetylenic molecular scaffolding in one, two and three dimensions. Finally, progress in the construction and properties of oligomers and polymers with a poly(triacetylene) backbone, the third linearly conjugated, non-aromatic all-carbon backbone, will be reviewed. 

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