Three-dimensional molecular scaffolding

We have shown how templated synthesis approaches are currently revolutionizing the covalent chemistry of fullerenes. They provide elegant and imaginative protocols to produce highly selectively functionalized fullerene building blocks for three-dimensional molecular scaffolding. 

The topological state index (T ) of an atom represents the position of the atom in the scaffold of the molecular structure in relation to aU other atoms of the molecule (hut based on topology, i.e., on the connectivity and not on the three-dimensional structure) [54], Chemically and topologically equivalent atoms have identical indices. 

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