Sarin long-term effects

Duffy, F.H. and J.L. Burchfiel. 1980. Long-term effects of the organophosphate sarin on EEGs in monkeys and humans. Neurotoxicol. 1 667-689. 

The results of these studies suggest some long-term effects of sarin toxicity and careful follow-up and observation are indicated in these victims. 

Sharp, D. (2006). Long-term effects of sarin. Lancet 14 367(9505), 95-7. 

Yanagisawa, N., Morita, H., Nakajima, T. (2006). Sarin experiences in Japan acute toxicity and long-term effects. J. Neur. Sci. 249 76-85. 

Kassa, J., Koupilova, M., Vachek, J. (2001c). Long-term effects of low-level sarin inhalation exposure on the spatial memory of rats in T-maze. Acta Med. (Hradec Kralove) 44 93-6. 

Unfortunately, there are no data on the long-term effects of nerve agent poisoning in children, and the effects must be extrapolated from what has been discovered in the adult population (Rotenberg and Newmark, 2003). Surveillance studies performed on victims of the sarin attacks in Japan revealed a wide range of sequelae, such as continued respiratory problems, vision disturbances, headache, and fatigue. Neuropsychiatric problems were also reported as a delayed effect. 

Grauer, E. and J. Kapon. 2004. Stress exposure and sarin poisoning interaction of long-term effects. Israel J Psychiatry 41(1) (abstract). 

Long-term effects of sarin poisoning need to be monitored more closely in the future and a well-designed large-scale study needs to be carried out. 

The possibility of long-term health effects associated with iow-dose exposure to chemical warfare agents has been a controversial Lssue. A 1982 National Academy of Sciences report could not rule out the possibility of longterm effects. The Japanese terrorist attacks with sarin during the 1990s provided evidence of the long-term effects of... 

These are related to organophosphorus insecticides and they include some of the most powerful poisons known to science. They act by inhibition of the enzyme acetylcholinesterase. Most act extremely rapidly within seconds and at very low concentration. Agonising death results from inhalation, ingestion or skin absorption. Best known are DFP, Tabun, Sarin and VX (Chapter 12.13). There may also be serious long-term effects arising from exposure to concentrations below levels which produce any immediately obvious effects. 

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