Sampling materials, storage

The checklist is divided into three areas 1) Material Storage and Handling, 2) Production Processes and 3) Treatment Alternatives. Material degradation, samples, spills, storage, and inspections are addressed in the first section. Production processes include source reduction for process bath solutions and rinse systems, resource recovery and recycling, and solvent management. Treatment Alternatives focuses on process water pretreatment, modification of conventional wastewater treatment, and alternative waste treatment methods. Each of these subsections follow the question and answer format. 

Materials management (receipt, quarantine, sampling, testing, storage, and re-evaluation)... 

Figure 11 Physical changes occurring to SQ-33600 disodium salt during solid-formulation processes as described using PXRD analysis. Sample A represents the initial wet-granulated amorphous material. Samples B and C represent samples following storage at 52% RH and 75% RH, respectively.

Materials that come in contact with the blank and the samples may also be the source of contamination. Laboratory equipment for sample preparation, storage, and analysis must be made of non-reactive materials compatible with the chemical reagents equipment used in sample digestion must be thermally stable. Quartz glass, PTFE, and polyethylene are common non-contaminating materials used in elemental analysis procedures. 

A conveniently situated, modest-sized (approximately 120-square-foot) storage area would suffice and it should be smooth, light colored, linoleum floored with Formica type shelving, non-heated, and dry. (Bear in mind that some sampling kits contain flammable solvents.) The store should be lock-able and under the directed control of an appointed officer and used exclusively for the storage of suspect sampling materials for use at that location only. There must be a strict accounting system for all materials. 

Once the material has been chosen for sampling and storage, it is important to establish a protocol for the collection of milk samples. The extraction will be achieved manually or by means of a plastic milk extractor, a new one for each sampling. The nipple and the skin around it should be cleaned with soap and distilled water before collection. The milk thus collected should then be stored in plastic containers previously decontaminated, as explained above. The containers should be labeled and kept at — 20°C until analysis. 

Another relevant variable is the dosage form when a herbal tea is prepared by hot extraction from valerian root, up to 60% of the valepotriates remain in the root material and only 0.1% can be recovered from the tea. A freshly prepared tincture contains 11% of the valepotriates originally found in the root material. Storage at room temperature rapidly reduces this to 3.7% after 1 week and 0% after 3 weeks. In view of this rapid degradation, it is not surprising that commercially available tincture samples yield baldrinals. 

Sample material Serum or plasma (EDTA, citrate, heparin or oxalate). Storage life one week in the refrigerator ( <-2°C to +8 C). 

Sample material Serum only. Storage life of serum 1 week in the refrigerator... 

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