Salmonella thompson

Aavitsland, P. and Nygard, K. (2004) Outbreak of Salmonella Thompson Infections. MSIS - Norwegian Surveillance System for Communicable Diseases. 

Thompson, T.B. Thomas, M.G. Escalante-Semerena, J.C. Rayment, L Three-dimensional structure of adenosylcobinamide kinase/adenosylcobina-mide phosphate guanylyltransferase from Salmonella typhimurium determined to 2.3 A resolution. Biochemistry, 37, 7686-7695 (1998)... 

Thomas, M.G. Thompson, T.B. Rayment, I. Escalante-Semerena, J.C. Analysis of the adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase (CobU) enzyme of Salmonella typhimurium LT2. Identification of residue His-46 as the site of guanylylation. J. Biol. Chem., 275, 27576-27586 (2000)... 

Minnich, V., M.E. Smith, D. Thompson, and S. Kornfeld. Detection of mutagenic activity in human urine using mutant strains of Salmonella typhimurium. Cancer 38 1253-1258, 1976. 

Thompson, P.W. (2005) tVS5 Pure reverse mutation assay Ames test" using Salmonella typhimurium and Escherichia coli. Unpublished report prepared by SafePharm Laboratories, Derbyshire, United Kingdom, for the Flavor and Extract Manufacturers Association, Washington, DC, USA. Submitted to WHO by the International Organization of the Flavor Industry, Brussels, Belgium (SPL Project No. 1044/068). 

Typically, blends of organic acids, representing an array of pK optima, are more effective against Salmonella spp. than single acids alone. This synergism, demonstrated by Thompson and Hinton (1997), demonstrated improved efficaey from a eombination of propionic and formic acids when compared to single acids. 

Thompson, J.L. and Hinton, M. (1997) Antibacterial activity of formic and propionic acids in the diet of hens on salmonellas in the crop. British Poultry Science. 38 (1) 59. 

Trp-P-2 and IQ have been evaluated in a repair-deficient Chinese hamster cell forward mutation system (Thompson et al., 1983). Trp-P-2 was very potent for producing mutations at both the hprt and aprt loci in both the repair competent AA8 cell line and the repair incompetent UV-5 line (see figure 1). In contrast to these results, IQ was quite weak. Equivalent mutation and toxicity effects were seen only at doses of IQ that were 70-100 fold higher than used for Trp-P-2. With IQ, toxicity differences were seen between the repair proficient and deficient strains. These results indicate that some of the damage leading to toxicity produced by IQ is not repairable by the excision repair pathway. Also, only the repair deficient strain showed a mutagenic response. Thus, in contrast to Salmonella, the CHO cells are much more responsive to Trp-P-2 than to IQ. 

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