Salmonella mutagenicity prediction

Helma C (2006) Lazy structure-activity relationships (lazar) for the prediction of rodent carcinogenicity and salmonella mutagenicity. Mol Divers 10 147-158... 

Zeiger E. 1987. Carcinogenicity of mutagens Predictive capability of the Salmonella mutagenesis assay for rodent carcinogenicity. Cancer Res 47(5) 1287-1296. 

Blackburn GR, Deitch RA, Schreiner CA, et al. 1986. Predicting carcinogenicity of petroleum distillation fractions using a modified Salmonella mutagenicity assay. Cell Biol Toxicol 2 63-84. 

The prediction of genotoxicity based on chemical structure began in earnest after Ashby and Tennant [15,16] established that there are correlations between chemical structure. Salmonella mutagenicity and carcinogenicity - and that genotoxic and... 

Zeiger E, Ashby J, Bakale G, Enslein K, Klopman G, Rosenkranz FIS. Prediction of Salmonella mutagenicity. Mutagenesis 1996 Sep ll(5) 471-84. 

Table 17 Ames mutagenicity data for Salmonella typhimurium TA100 and physicochemical parameters for A-acyloxy-A-alkoxyamides together with predicted activities according to QSAR (Equation 4)... 

McCann, J. Ames, B. "The Salmonella/Microsome Mutagenicity Test Predictive Value for Animal Carcinogenicity " in "Origins of Human Cancer " Hiatt, H. H., Watson, J. D., Winsten, J. A., Eds., Cold Springs Harbor Laboratory Cold Springs Harbor, New York, 1977, pp. 1431-50. 

McCann, J. and Ames, B. N., The Salmonella/Microsome Mutagenicity Test Predictive Value for Animal Carcinogenicity, (p. 1431 in ref. 1)... 

Some dyes exhibit a mutagenic potential. The Ames test is commonly used as a first screening for the prediction of mutagenicity of a substance. It is a bacterial point mutation test inducing activity, which uses special strains of the bacteria Salmonella typhimurium with growth-dependence on the amino acid histidine. The dose-dependent reversion to histidine-independent growth is the marker for a point mutation. 

Large-scale mutagenicity testing is already under way. More than 12,000 chemicals had been tested by early 1981, mostly in Salmonella or mammalian cell-culture systems.11 Data are accumulating rapidly, and regulatory agencies must decide what test data are most appropriate for predicting risks to human health. 

McCann, J., and B.N. Ames. The Salmonella/microsome mutagenicity test predictive value for animal carcinogenicity, pp. 87-108. In W.G. Flaimn and M.A. 

Table 2 MultiCASE predictions (version 1.55) using the single strains mutagenicity for salmonella (A2K-A2Z) modules for 1441 Aventis proprietary structures.

FIGURE 11.4. The MDL-QSAR version 2.2.2.0.7 prediction for mutagenic potential of onchidal in Salmonella typhimurium. 

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