Salmonella mutagenicity assay

Ashwood-Smith, M.J. (1980). Stability of frozen microsome preparations for use in the Ames Salmonella mutagenicity assay. Mutation Res. 69 199-200. 

Dirven HA, Theuws JL, Jongeneelen FJ, et al. 1991. Non-mutagenicity of 4 metabolites of di(2-ethylhexyl)phthalate (DEHP) and 3 structurally related derivatives of di(2-ethylhexyl)adipate (DEHA) in the salmonella mutagenicity assay. Mutat Res 260 121-130. 

Blackburn GR, Deitch RA, Schreiner CA, et al. 1986. Predicting carcinogenicity of petroleum distillation fractions using a modified Salmonella mutagenicity assay. Cell Biol Toxicol 2 63-84. 

Prival MJ. 1983. The Salmonella mutagenicity assay Promises and problems. Ann NY Acad Sci 407 154-163. 

Biagi, L.G., Hrelia, P., Gerra, M.G., Paolini, M., Barbaro, A.M. and Cantelli-Forti, G., Structure-activity relationships of nitroimidazo (2,1-b) thiazoles in the salmonella mutagenicity assay,Arch. Toxicol., Suppl. 9, 425 129, 1986. 

Callander, R.D., and K.P. Priestley. 1990. HFC-134a An Evaluation Using the Salmonella Mutagenicity Assay. ICI Rep. No. CTL/P/2422. Central Toxicology Laboratory. Imperial Chemical Industries, Alderley Park, Macclesfield, Cheshire, U.K. 

Ampy FR, Saxena S, Verma K. 1988. Mutagenicity of benzo-a-pyrene in uninduced tissues from Balb-c mice and Sprague-Dawley rats as an index of possible health risks using the Salmonella mutagenicity assay. Cytobios 56(225) 81-88. 

Raineri, R., Poiley, J. A., Pienta, R. J., and Andrews, A. W., Metabolic activation of carcinogens in the Salmonella mutagenicity assay by hamster and rat liver S9 preparations. Environ. Mutag. 3 71-84 (1981). 

Relate mutagens and carcinogens. Outline the Ames Salmonella mutagen assay. 

Kwon, D., Yoon, S., Carter, O., Bailey, G.S., and Dashwood, R.H. 2006. Antioxidant and an-tigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCTl 16 human colon cancer cells. BioFactors, 26(4), 231-244. doi 10.1002/biof5520260402. 

F. J. de Serres and M. D. Shelby, The Salmonella mutagenicity assay Recommendation,... 

Although the Salmonella mutagenicity assay is valuable in detecting carcinogens, there are several classes of chemical carcinogens that cannot be detected as mutagens in the standard Salmonella assay. It would... 

The limits of the sensitivity of the standard pol A procedure (lowest effective dose) for a number of chemicals have been compared to the dose required to give a positive test in the Salmonella mutagenicity assay (Table 5). For the chemicals selected that are active in both systems, it was found that there was no definite trend. The Salmonella assay was exquisitely sensitive to some chemicals (e.g., aflatoxin Bi), while the pol A system responded to low levels of others (e.g., mitomycin C). 

TABLE 5. Comparison of Sensitivity of Standard Pol A Assay and the Salmonella Mutagenicity Assay ... 

The fumonisins have been associated with human cancer (32, 77), although the mechanism of carcinogenicity is unknown. FBi was not found to be mutagenic in the Salmonella mutagenicity assay and was not genotoxic in DNA repair assays (65). The fumonisins appear to act mainly as tumor promoters. 

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