Salicylic acid recognition

N-ethylmaleimide-sensitive factor peptidoglycan pathogenesis-related pattern recognition receptors Pseudomonas syringae pv. tomato receptor-like kinases reactive oxygen species salicylic acid... 

Gunnlaugsson, T., Harte, A.J., Leonard, J.R, and Nieuwenhuyzen, M. (2002) Delayed lanthanide luminescence sensing of aromatic carboxylates using heptadentate triamide Tb(III) cyclen complexes the recognition of salicylic acid in water. Chemical Communications, 2134-2135. 

With the recognition that a Cu complex of histamine was responsible for its histaminic activity. Walker and Reeves [116] suggested that a competition for this Cu accounted for the well-known observation that salicylic acid has antihistamine activity. They then demonstrated that salicylic acid prevented lethality in mice given an LDso dose of histamine. Since an increase in vascular permeability is an important physiological response in inflamed tissues, these observations merit in-depth study. 

It is a relatively recent observation that Colchicum species contain numerous chemical constituents of diverse chemical properties. Recognition of this fact has led to more efficient methods of isolation. In addition to neutral, phenolic, and basic alkaloids, 0. autumnale contains fatlike substances which are removed by a preliminary ligroin extraction of the pulverized, dry material. From such an extraction of the flowers of C. autumnale, Santavy and Herout (293) have isolated a paraffin, Ca7-28H5g 58, m.p. 58-60° an alcohol, CaaH450H, m.p. 66-67° and a phytosterol, m.p. 139-140°. Benzoic, salicylic, and 2-hydroxy-6-methoxybenzoic acids may be separated from the alkaloid mixture by virtue of their solubility in ether and aqueous base (294). The alkaloids themselves may be separated into neutral, phenolic, or basic fractions by standard extraction techniques. Pure alkaloids may be obtained from each fraction by fractional crystallization and chromatography on... 

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