Saccharomyces cerevisiae prions

Bousset, L., Redeker, V., Decottignies, P., Dubois, S., Le Marechal, P., and Melki, R. (2004). Structural characterization of the fibrillar form of the yeast Saccharomyces cerevisiae prion Ure2p. Biochemistry 43, 5022-5032. 

Thual, C., Komar, A. A., Bousset, L., Fernandez-Bellot, E., Cullin, C., and Melki, R. (1999). Structural characterization of Saccharomyces cerevisiae prion-like protein Ure2./. Biol. Chem. 274, 13666-13674. 

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This chapter focuses on recent advances in our understanding of the molecular processes underlying the inheritance and functional consequences of the Saccharomyces cerevisiae prion P.SY+. An expanded discussion of the history of PSI+ including a summary of evidence supporting its classification as a yeast prion can be found in Volume 57 of Advances in Protein Chemistry (Serio and Lindquist, 2001). 

Wickner, R. B. (1994). [URE3] as an altered URE2 protein Evidence for a prion analog in Saccharomyces cerevisiae. Science 264, 566—569. 

Baxa, U., Speransky, V., Steven, A. C., and Wickner, R. B. (2002). Mechanism of inactivation on prion conversion of the Saccharomyces cerevisiae Ure2 protein. Proc. Natl. Acad. Sci. USA 99, 5253-5260. 

Bousset, L., Belrhali, H., Janin,J., Melki, R., and Morera, S. (2001a). Structure of the globular region of the prion protein Ure2 from the yeast Saccharomyces cerevisiae. Structure 9, 39-46. 

Orlowska-Matuszewska, G., and Wawrzycka, D. (2006). A novel phenotype of eight spores asci in deletants of the prion-like Rnqlp in Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 340, 190—193. 

DePace AH, Santoso A, Hillner P, Weissman JS (1998) A critical role for amino-terminal glu-tamine/asparagine repeats in the formation and propagation of a yeast prion. Cell 93 1241-1252 Didichenko SA, Ter-Avanesyan MD, Smirnov VN (1991) Ribosome-bound EF-1 alpha-like protein of yeast Saccharomyces cerevisiae. Eur J Biochem 198 705-711 Dong H, Kurland CG (1995) Ribosome mutants with altered accuracy translate with reduced processivity. J Mol Biol 248 551-561... 

Eaglestone SS, Cox BS, Tuite MF (1999) Translation termination efficiency can be regulated in Saccharomyces cerevisiae by environmental stress through a prion-mediated mechanism. EMBO J 18 1974-1981... 

Further evidence for the phenomenon of self-propagating protein conformers was provided by the discovery of proteins with prion-like properties in the budding yeast Saccharomyces cerevisiae [41]. The chapter by Mick Tuite [165, 166] in this book will provide a detailed review about fungal prions and their cellular functions. In addition, it has been reported that the translation regulator CPEB from Aplysia can act as a self-sustaining prion-like protein in the nervous system [42—44]. 

Keywords Molecular chaperone Podospora anserina Prion Prion propagation Propagons Yeast Saccharomyces cerevisiae)... 

Table 1 Prions and putative prion proteins in the yeast Saccharomyces cerevisiae...

Du Z, Park KW, Yu H, Fan Q, Li L (2008) Newly identified prion linked to the chromatinremodeling factor Swil in Saccharomyces cerevisiae. Nat Genet 40 460-465... 

Byrne LJ, Cole DJ, Cox BS, Ridout MS, Morgan BJ, Tuite MF (2009) The number and transmission of PSI+] prion seeds (propagons) in the yeast Saccharomyces cerevisiae. PLoS ONE 4 e4670... 

Derkatch IL, Bradley ME, ZhouP, Chemoff YO, Liebman SW (1997) Genetic and environmental factors affecting the de novo appearance of the PS1+] prion in Saccharomyces cerevisiae. Genetics 147 507-519... 

Derkatch IL, Chemoff YO, Kushnirov VV, Inge-Vechtomov SG, Liebman SW (1996) Genesis and variability of [PS/] prion factors in Saccharomyces cerevisiae. Genetics 144 1375-1386... 

Moriyama H, Edskes UK, Wickner RB (2000) [URE3] prion propagation in Saccharomyces cerevisiae requirement for chaperone Hspl04 and curing by overexpressed chaperone Ydjlp. Mol Cell Biol 20 8916-8922... 

Jones G, Song Y, Chung S, Masison DC (2004) Propagation of Saccharomyces cerevisiae [PSI+] prion is impaired by factors that regulate Hsp70 substrate binding. Mol Cell Biol 24 3928-3937... 

Kryndushkin D, Wickner R (2007) Nucleotide exchange factors for Hsp70s are required for URE3] prion propagation in Saccharomyces cerevisiae. Mol Cell Biol 18 2149-2154... 

Reidy M, Masison D (2010) Stil regulation of Hsp70 and Hsp90 is critical for curing of Saccharomyces cerevisiae PS1+] prions by Hspl04. Mol Cell Biol 30 3542-3552... 

Resende CG, Outeiro TF, Sands L, Lindquist S, Tuite MF (2003) Prion protein gene polymorphisms in Saccharomyces cerevisiae. Mol Microbiol 49 1005-1017... 

Genesis and variability of [P57] prion factors in Saccharomyces cerevisiae. Genetics 144,1375-1386. 

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