Ribosomal, conservation

Alksne LE, Anthony RA, Liebman SW, Warner JR (1993) An accuracy center in the ribosome conserved over 2 billion years. Proc Natl Acad Sci USA 90 9538-9541 Allen KD, Wegrzyn RD, Chernova TA, Muller S, Newnam GP, Winslett PA, Wittich KB, Wilkinson KD, Chernoff YO (2004) Hsp70 chaperones as modulators of prion life cycle novel effects of Ssa and Ssb on the Saccharomyces cerevisiae prion [PS1+]. Genetics 169 1227-1242 All-Robyn JA, Kelley-Geraghty D, Griffin E, Brown N, Liebman SW (1990) Isolation of omnipotent suppressors in an [eta-t] yeast strain. Genetics 124 505-514... 

Ribosomes are ancient ribonucleoprotein complexes that are the sites of protein synthesis in living cells. Their core structures and fundamental functional mechanisms have been conserved throughout the three domains of life bacteria, archaea and eukaryotes. All ribosomes are organized into two subunits that are defined by their apparent sedimentation coefficient, measured in Svedberg units (S). There is a general... 

Dinos, G., Wilson, D. N., Teraoka, Y., Szaflarski, W., Fucini, P., Kalpaxis, D., and Nierhaus, K. H. (2004). Dissecting the ribosomal inhibition mechanisms of edeine and pactamycin The universally conserved residues G693 and C795 regulate P-site RNA binding. Mol. Cell 13, 113-124. 

Ginisty H, Serin G, Ghisolfi-Nieto L, Roger B, Libante V, Amalric F, Bouvet P (2000) Interaction of Nucleolin with an Evolutionarily Conserved Pre-ribosomal RNA Sequence Is Required for the Assembly of the Primary Processing Complex. J Biol Chem 275 18845-18850 Ginisty H, Sicard H, Roger B, Bouvet P (1999) Structure and functions of nucleolin. J Cell Sci 112 761-772... 

The new crystal structure of the ribosome—RFl complex sheds more light into the interactions between the GGQ motif and the peptidyltransferase center. This complex represents the product state of peptide release since a deacylated tRNA is bound to the P site. Importantly, the main chain amide of the conserved glutamine hydrogen bonds to the 3 OH of A76 in the P site, which is the leaving group of the hydrolysis... 

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