Rosiglitazone peroxisome proliferator-activated

Thiazolidinediones (PPARy-agonists) Thiazolidine-diones ( pioglitazone, rosiglitazone) lower blood glucose levels in animal models of insulin resistance and also in insulin resistant patients. They are agonists of the peroxisome proliferator-activated receptor y (PPARy). Because they enhance the effect of insulin and reduce serum insulin levels in insulin resistant patients, thiazolidinediones are usually referred to as insulin sensitizers . 

Thiazolidinediones (synonyms glitazones, insulin sensitizers rosiglitazone, pioglitazone) are a novel class of oral antidiabetic drugs that activate the transcription factor peroxisome proliferator-activated receptor (PPARy). Thiazolidinediones ameliorate insulin resistance in obese animal models and in individuals... 

Camp HS, Li O, Wise SC, Hong YH, Frankowski CL, Shen X, Vanbogelen R, Leff T. Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone. Diabetes 2000 49(4) 539 17. 

Philips J-C, Petite C, Willi J-P, Buchegger F, Meier CA. Effect of peroxisome proliferator-activated receptor 8 agonist rosiglitazone on dedifferentiated thyroid cancers. Nucl Med Comm 2004 25 1183-6. 

Sidhu JS, Cowan D, Kaski JC, The effects of Rosiglitazone, a peroxisome proliferator activated receptor gamma agonist, on markers of endothelial cell activation, C-reactive protein, and fibrinogen levels in non-diabetic coronary artery disease patients. J Am Coll Cardiol 2003 42 1757-1763. 

Churi, S. B., Abdel-Aleem, O. S., Tumber, K. K., Scuderi-Porter, H., and Taylor, B. K. (2008). Intrathecal rosiglitazone acts at peroxisome proliferator-activated receptor-gamma to rapidly inhibit neuropathic pain in rats. J. Pain 9, 639—649. 

Buckingham, R. E., Al-Barazanji, K. A., Toseland, C. 1). N. el al. (1998). Peroxisome Proliferator-Activated Receptor-y Agonist, Rosiglitazone, Protects Against Nephropathy and Pancreatic Islet Abnormalities in Zucker Fatty Rrts. Diabetes 47, 1326-1334. 

Rosiglitazone 9, an agonist of peroxisome proliferator activated receptor-y (PPARy), is a recently introduced antihyperglycemic thiazolidinedione effective in the treatment of noninsulin dependant diabetes mellitus (type II diabetes). A seven-step synthesis was developed (Scheme 3), which utilised supported reagents in combination with in-line SPE purifications. The introduction of the pyridine moiety provided a convenient molecular handle by which to purify the molecule throughout the synthesis. Notably, the overall yield (46%) for this synthesis was higher than the yield reported in the initial shorter solution-phase synthesis (31%). ... 

Thiazolidinediones (e.g., rosiglitazone 4) reduce insulin resistance (insuhn sensitizers). These compounds stimulate peroxisome-proliferator-activated receptors (PPARs) on the nuclear surface, leading to increased glucose uptake and reduced hepatic gluconeogenesis [50]. 

Grey, A., Bolland, M., Gamble, G. et al. (2007) The peroxisome proliferator-activated receptor y agonist rosiglitazone decreases bone formation and bone mineral density in healthy postmenopausal women a randomized,... 

Buckingham RE, Al-Barazanji KA, Toseland CD, et al. Peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats. Diabetes. 1998 47(8) 1326-1334. 

PPARy (peroxisome proliferated-activated receptor-y) activator in humans-rosiglitazone. 

Sun H, Huang Y, Yu X, Li Y, Yang J, Li R, Deng Y, Zhao G (2008) Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after hthium pilocarpine-induced status epilepticus in rats. Int J Neurosci 26 505-515... 

The thiazolidinediones (e.g. rosiglitazone) appear to decrease insulin resistance through activation of gamma-PPAR (peroxisome proliferator-activated receptor). They are used in type 2 diabetes. 

Thiazolidinediones (Gamma-PPAR (peroxisome proliferator-activated receptor) agonists) Pioglitazone, Rosiglitazone... 

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