Rosetta Stone method

Recently, the Rosetta stone method has been introduced. This method uses over 20 completely sequenced genomes and analyzes evolutionary correlations of two domains being fused into one protein in one species and occurring in separate proteins in another species. From these classifications the method establishes pairwise links between functionally related proteins [94] and elicits putative protein-protein interactions [95]. 

Rosetta stone method If two proteins occur separated in one organism and homologous proteins are fused in another organism, the former two proteins are candidates for being binding partners in the first organism [31]. 

Gene Fusions The Rosetta Stone Method STRING (http //string.embl.de/)... 

Figure 6.2. Domain fusion method to detect functional linkages between proteins. If two proteins, A and B, from a certain species are expressed as a single fused protein within another species, the proteins A and B are proposed to be functionally linked. Because the fusion protein contains homology to both A and B, it is termed a Rosetta Stone sequence. Specific examples from domain fusion analyses are shown. Figure adapted from Eisenberg et al. (2000) and Marcotte et al. (1999).

Written records provide a valuable glimpse into the thoughts and behavior of ancient peoples. But these records are not complete and omit important information (important, that is, to historians). Scientists studying the past have had to turn to other sources such as analyzing artifacts. Archaeological finds are a rich source of information, if that information can be unlocked. The need is to find a Rosetta stone for other types of artifacts—a method of gleaning all the information that is available. 

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