Rosacea topical therapy

These include atypical or subtle manifestations of dermatologic conditions such as seborrheic dermatitis, rosacea, psoriasis, atopic dermatitis, and ichthyosis. Classic manifestations of such diseases are diagnosed with relative ease. However, diagnostic difficulty arises in the presence of atypical morphology, lesions masked by topical therapy (e.g., corticosteroids), or exacerbations due to other topical agents (e.g., skin care products).2,10... 

Nally JB, Berson DS (2006) Topical therapies for rosacea. J Drugs Dermatol 5 23-26... 

In most instances patients demonstrate significant improvement of clinical symptomatology and physical signs in the first 2 to 3 weeks. Many patients, however, require chronic therapy and demonstrate exacerbations of the disease during its course. Metronidazole (MetroGel) is a topical gel developed to treat the skin of the facial area in patients with chronic disease and thus reduce the reliance on oral antimicrobial agents. It is applied twice daily. Although not yet an approved use, metronidazole gel applied to the eyelids was found to be an effective treatment of ocular rosacea. 

Reduces active acne and rosacea lesions and seborrhea. Accelerates efficacy of topical and systemic acne therapy. 

Demodexfolliculorum would be more common in pap-ulopustular [10, 11] and steroid rosacea [5, 14], In 1981, Rufli et al. [13] observed that mite prevalence increases with the age and that the search for the mite is positive in almost 100% of elderly healthy subjects. These results were confirmed in a study by Crawford et al. [16], who stated that Demodex is found in a large number of healthy persons. In fact, with modem and sensitive techniques, the prevalence in healthy adults approaches 100%. Consequently, the simple identification of Demodex is by no means proof of pathogenesis. Furthermore, at least four studies [13,14,17,18] clearly demonstrated that specific therapies, both topical and systemic, Against Demodex folliculorum do not reduce the amount of the mite, but they improve the disease according to the chnical point of view. On the basis of the results of all these studies, the search for Demodexfolliculorum in a patient with rosacea is neither necessary nor helpful for therapy. 

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