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Roferon A interferon

Interferon alfa-2a (Roferon A), interferon alfa-2b (Intron-A), and interferon alfacon-1 (Infergen) are approved for chronic hepatitis C. However, they are not prescribed alone because only 12% to 16% of patients achieve a sustained virologic response (SVR). Adding ribavirin, a synthetic guanosine analogue that inhibits viral polymerase, increases the SVR rate to 35% to 45%. [Pg.356]

Roferon-A Interferon a-2a Hoffman-La Roche Hairy cell leukemia, AIDS-related Kaposi s sarcoma, myelogenous leukemia, hepatitis C,... [Pg.695]

Drug(s) Biologic response modifiers Interferons Interferon alfa-2a [Roferon-A] Interferon alfa-2b [Intron-A] Primary Antineoplastic Indication(s) Hairy-cell leukemia Kaposi sarcoma chronic myelocytic leukemia renal and bladder cancers Common Adverse Effects Flulike syndrome [mild fever, chills, malaise]... [Pg.578]

Note that figures are unavailable for Roferon a-interferon, Recombinvax hepatitis B vaccine, and antihemophilia blood clotting such as Kogenate and Recombinate. [Pg.689]

Avastin - bevacizumab Hydrea - hydroxyurea Roferon-A - interferon alfa-2a... [Pg.395]

Interferon alfacon-1 (Inferax ), interferon alfa-2b (IntronA ), and interferon alfa-2a (Roferon -A) are applied in the treatment of chronic hepatitis B and C and some malignancies, especially hairy cell leukemia. IFN-a proteins induce the expression of antiviral, antiproliferative and immunomodulatory genes. [Pg.411]

Interferon alfa-2a Interferon alfa-2b 18 million IU 18 million IU 209.58 218.04 Roferon-A Intron-A ... [Pg.185]

Interferon alpha (Roferon-A) Lamivudine (Epivir, Epivir-HBV)... [Pg.412]

Recommended dosage and monitoring requirements The recommended dose of Roferon-A for chronic hepatitis C is 3 million international units (MIU) three times a week for 12 months. The recommended dose for CML is 9 MIU daily optimal duration of therapy has not been determined. The recommended dose for hairy cell leukemia is 3 MIU daily for 16 to 24 weeks. The recommended dose for AIDS-related Kaposi s sarcoma is 36 MIU daily for 10 to 12 weeks. There are five types of interferon alfa currently available in the United States interferon alfa-2a, peginterferon alfa-2a, interferon alfa-2b, interferon alfacon-1, and interferon alfa n3. Doses are not consistent for these preparations. [Pg.190]

Pharmacokinetics A mean elimination half-life of approximately 5 hours has been reported after intravenous doses of Roferon-A. Pharmacokinetic parameters are similar in healthy subjects and cancer patients after intramuscular doses. Dose-proportionate increases in serum levels occur with doses up to 198 MIU. The bioavailability of interferon alfa-2a after intramuscular administration is 80% to 83%, and its volume of distribution is 0.223 to 0.748 liter/kg. The total body clearance of interferon alfa-2a has been reported to range from 2.14 to 3.62ml/min per kg. [Pg.191]

F. Role in therapy According to Micromedex, Roferon-A is recommended as the drug of choice in renal carcinoma and the chronic phase of chronic myelogenous leukemia. The role of Gleevec (Ima-tinib) in CML is yet to be determined, but it may replace the use of interferon alfa-2a. Roferon-A is an alternative (for unrespon-sive/intolerant patients) to current regimens of choice in hairy-cell leukemia, multiple myeloma, metastatic melanoma, and AIDS-related Kaposi s sarcoma. Other alpha interferons appear to have similar efficacy and can be used in lieu of Roferon-A in some instances. In particular, interferon alfa-2b (Intron) can be considered to have the same role as interferon alfa-2a in chronic hepatitis C, Kaposi s sarcoma, and hairy-cell leukemia. [Pg.191]

Interferons and cytokines Interferon alfa-2a Roferon-A Sterile solution, SDV and prefilled syringes containing 3, 6,9,36MIU IV, SC... [Pg.461]

Parenteral 100 mg lyophilized powder for IV injection Interferon alfa-2a (Roferon-A)... [Pg.1360]

Interferon alfa-2a Roferon-A (Roche) Hairy cell leukemia AIDS-related Kaposi s sarcoma Chronic myelogenous leukemia... [Pg.271]

Taguchi T. Chnical studies of recombinant interferon alfa-2a (Roferon-A) in cancer patients. Cancer 1986 57(Suppl 8) 1705-8. [Pg.1842]

Interfemn AJfa-2a (Recombinant). Interferon alfa-2a (recombinant). Roferon A. is expressed in ui AT. < /i system and purilled by using high-afllnily tiuiusc monoclonal antibody chromatography. The protein consists of 165 amino acids with a molecular mass of approximately 19.000 Da. and contains lysine at position 21 and hi.siidine at position 14. [Pg.180]

Interferon a2aand a2b 166 amino acids Roferon A(Hoffmann-La Roche) Actimmune (Genentech) E. coli Treatment of various cancers and viral diseases... [Pg.431]

Interferon alfa (interferon o -2b Intron A and Interferon o -2a Roferon-A, IFN) ... [Pg.2311]

USA interferon alfa2a interferon Roferon-A Roceron-A, Alphaferon, Canferon A Recombinant interferon alfa2a with Lys 23 and His 34 substitutions expressed in E. coli Anti-cancer... [Pg.472]

See other pages where Roferon A interferon is mentioned: [Pg.190]    [Pg.515]    [Pg.515]    [Pg.328]    [Pg.957]    [Pg.250]    [Pg.676]    [Pg.328]    [Pg.190]    [Pg.515]    [Pg.515]    [Pg.328]    [Pg.957]    [Pg.250]    [Pg.676]    [Pg.328]    [Pg.1418]    [Pg.405]    [Pg.354]    [Pg.79]    [Pg.639]    [Pg.556]    [Pg.1089]    [Pg.44]    [Pg.1154]    [Pg.575]    [Pg.373]    [Pg.441]    [Pg.861]    [Pg.331]    [Pg.754]    [Pg.2516]   
See also in sourсe #XX -- [ Pg.815 ]



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