RNA modification database

Histone database RNA structure database RNA modification database European large subunit rRNA database http //genome.nhgri.nih.gov/histones/ http // mabase.org http //medlib.med.utah.edu/RNAmods http //rma.uia.ac.be/lsu/index.html... 

RNA modification database at http //medlib.med.utah.edu/RNAmods furnishes information concerning naturally modified nucleosides in RNA (Limbach et al., 1994). After clicking Search, select individual files (pick corresponding radios under categories base type, RNA source, and phylogenetic occurrence) to be accessed, and output options (common name, structures, and/or mass values). Enter partial name (i.e., substituent name such as methyl, thio, etc.) and choose the parent base(s) from which modified nucleosides are derived (Figure 5.8). Click Search button. The tabulated search results based on selected files are returned according to the requested output options. 

Figure 5.8. Search form for RNA modification database. To search the database, only one radio from each category can be selected, however, multiple selections from the output (show) boxes are possible. Partial name is optional, and more than one partial name can be entered if they are separated by a space.

LIPID Membrane lipid structures Merck manual Monosaccharide database Mptopo Membrane protein topology PDB 3D structures of biomacromolecules RNA modification database RNA Structure database Spectral Database Systems (SDBS)... 

Limbach PA, Crain PF, McCloskey JA. Summary the modified nucleosides of RNA. Nucleic Acids Res. 1994 22 2183-2196. Rozenski J, Crain PF, McCloskey JA. The RNA modification database 1999 update. Nucleic Acids Res. 1999 27 196-197. Beaucage SL, Iyer RP. The synthesis of modified oligonucleotides by the phosphoramidite approach and their applications. Tetrahedron 1993 49 6123-6194. 

Transfer RNA from all organisms contains modified nucleosides. Most of them play an important role in the fine tuning of tRNA activity. The presence of a modified nucleoside improves the efficiency of the tRNA in the decoding event, and may affect the fidelity of protein synthesis and codon choice such as the modified nucleoside next to the 3 -side of the anticodon (position 37) and at the Wobble position (position 34). Modified nucleosides in the anticodon region, other than positions 34 and 37, may influence the translational efficiency and fidelity, whereas those outside the anticodon region may stabilize tRNA conformations. Useful information concerning modified nucleosides in RNA is available from RNA modification database at http //medlib.med.utah.edu/RNAmods. 

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