Monosaccharides database

Monosaccharide database http //www.cermav.cnrs.fr/databank/mono/... 

Figure 5.5. Search result of monosaccharide database. The web site provides 2D and 3D structures of monosaccharides. The chair conformer of methyl 2-amino-2-deoxy-/ -D-glucopyranoside in which all hydroxy (1-methoxy and 2-amino) groups are equatorial is displayed.

LIPID Membrane lipid structures Merck manual Monosaccharide database Mptopo Membrane protein topology PDB 3D structures of biomacromolecules RNA modification database RNA Structure database Spectral Database Systems (SDBS)... 

Studies indicate that whereas glucose almost exclusively assumes its pyranose form in aqueous solution, fructose is 67% pyranose and 33% furanose, and ribose is 75% pyranose and 25% furanose, although in polysaccharides, glucose, fructose, and ribose residues are exclusively in their respective pyranose, furanose and furanose forms. The monosaccharide database accessible at http //www.cermav.cnrs.fr/databank/mono/ provides structural information on monosaccharides. 

KEGG, biosynthetic pathways Klotho of biochemical compounds Monosaccharide database ... 

Figure 14.11. Construction of biopolymer with HyperChem. Two menus are available for creating 3D structure models in HyperChem. The Build menu provides tools for creating organic molecules. Use the Drawing tool to sketch atoms in a molecule and connect them with covalent bonds. Invoke the Model builder to create a 3D structure from the 2D sketch. The Databases menu offers tools for creating biopolymers from residues with user specified linkages and conformations—that is, polysaccharides from monosaccharides, polypeptides form amino acids, and polynucleotides from nucleotides. A double-stranded DNA chain, for example, is constructed from nucleotide residues in a desired conformation (the inset).

The key to this approach is to have extensive quantitative data regarding the relative reactivities of different protected monosaccharides. Thus, a reactivity database on pro-tectedp-methylphenylthiogly cosides was generated and used as the basis of a computer program that selects the best reactants for one-vessel synthesis of oligosaccharides (104). 

Carbohydrates constitute one the of most complex structures occurring in nature (with nucleic acids and proteins) due to i) the monosaccharide diversity, ii) the type of linkage and iii) the nature of carbohydrate-linked molecules. As a result, GHs present a wide range of activities, which have necessitated the creation of a specific classification more explicit than the lUB Enzyme Nomenclature. In 1998, the Carbohydrate-Active Enzymes (CAZy) database was created, gathering glycosidases in famiUes based on amino-acid sequence and protein structures similarities. ... 

Once sugars were chosen as the basis of the database, the next consideration was to decide upon a standard graphical representation from which connection tables and the h3q)erstructure data could be derived. The Fischer representation was selected because monosaccharide units would then be represented the same way... 

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