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Ritalin LA

Capsules, extended-release 10, 20, and 30 mg c-ii) Metadata CD (Celltech), Ritalin LA (Novartis)... [Pg.1150]

ER capsules (Ritalin LA, Metadata CD) Administer once daily in the morning before... [Pg.1152]

Sprinkle administration-The capsules may be carefully opened and the beads sprinkled over a spoonful of applesauce. The applesauce should not be warm because it could affect the modified release properties of Ritalin LA. The mixture of drug and applesauce should be consumed immediately in its entirety. Drinking some fluids (eg, water) should follow the intake of the sprinkles with applesauce. The drug and applesauce mixture should not be stored for future use. [Pg.1153]

Patients currently using methylphenidate - The recommended dosage of Ritalin LA for patients currently taking methylphenidate twice daily or SR is provided in the following table. For other methylphenidate regimens, use... [Pg.1153]

Previous Methylphenidate Dosage Recommended Ritalin LA Dosage... [Pg.1153]

Ritalin LA Ritalin LA produces a bimodal plasma concentration-time profile (2 distinct peaks approximately 4 hours apart) when orally administered. [Pg.1154]

Antacids/Acid suppressants (Ritalin LA only) Because the modified release characteristics of Ritalin LA capsules are pH dependent, the coadministration of antacids or acid suppressants could alter the release of methylphenidate. Clonidine Serious adverse reactions have been reported in concomitant use with clonidine, although no causality for the combination has been established. [Pg.1156]

Brand Name(s) Concerta, Metadate CD, Metadate ER, Methylin, Methylin ER, Ritalin, Ritalin LA, Ritalin SR... [Pg.787]

Methylphenidate and D-amphetamine are both short-acting compounds, with an onset of action within 30 to 60 minutes and a peak clinical effect seen usually between 1 and 2 hours after administration, lasting 2 to 5 hours. Therefore, multiple daily administrations are required for a consistent daytime response. The amphetamine compound Adderall, the sustained-release preparations of methylphenidate and dextroamphetamine, and pemoline are all intermediate-acting compounds with an onset of action within 60 minutes and a peak clinical effect seen usually between 1 and 3 hours after administration and maintained for up to 8 hours (8 hours with metadate C.D. and Ritalin LA 12 hours with Concerta), allowing for a single dose for the entire school day. Adderall XR is a 12 hour preparation. [Pg.448]

Methylphenidate (Ritalin, Methylin, (Metadate) (Concerta) (Ritalin LA) d-Methylphenidate (Focalin)... [Pg.449]

Metadate-CD, Ritalin-LA, Focalin, others Dexedrine 5 mg t 5, 10, 15 mg sustained-release spansules Adderall 5, 10, 20, 30 mg... [Pg.757]

Ritalin LA 1-3 (initial peak) 5-11 (second peak) 2.5 (children) 3.5 (adults) 8-9... [Pg.176]

Ritalin LA ADHD Children >6 years old Start at 20 mg once daily (or lower at clinician s discretion) increase by 10 mg weekly. [Pg.179]

Start Ritalin LA at total daily dose of immediate-release methylphenidate or methylphenidate-SR (administer Ritalin LA dose once daily). [Pg.179]

Methylphenidate Ritalin-SR Ritalin LA Metadate ER Metadate CD Concerta Slowly absorbed tablet Capsule with 50% methylphenidate dose as immediate-release beads and 50% as delayed-release beads Slowly absorbed tablet with methylphenidate incorporated in a wax matrix tablet, allowing gradual diffusion Capsule that provides 30% of methylphenidate dose hy immediate-release beads and 70% of the dose by extended-release beads Tablet that contains approximately 22% of the methylphenidate dose in an immediate-release capsule overcoat and 78% within the tablet that is released by an osmotic process over an extended period... [Pg.185]

Source. Adderall XR 2004 Connor and Steingard 2004 Focalin XR 2005 Physicians Desk Reference 2005a Ritalin LA 2004. [Pg.185]

Ritalin LA, which contains half the methylphenidate dose in immediate-release heads and half the dose in enteric-coated, delayed-release heads, is also intended to provide efficacy throughout at least the school day (Biederman et al. 2003 Lopez et al. 2003). [Pg.186]

Biederman J, Quinn D, Weiss M, et al Efficacy and safety of Ritalin LA, a new, once daily, extended-release dosage form of methylphenidate, in children with attention deficit hyperactivity disorder. Paediatr Drugs 5 833-841, 2003... [Pg.194]

Lopez F, Silva R, Pestreich L, et al Comparative efficacy of two once daily methylphenidate formulations (Ritalin LA and Concerta) and placebo in children with attention-deficit hyperactivity disorder across the school day. Paediatr Drugs 5 545-555, 2003... [Pg.195]

Ritalin LA (package insert). East Hanover, NJ, Novartis Pharmaceutical Corp, 2004... [Pg.198]

Ritalin LA and Metadate CD (up to 8 hours duration of action) initial 20 mg once daily dosage may be adjusted In weekly 10 mg increments to a maximum of 60 mg/day taken in the morning... [Pg.123]

The newer sustained release Ritalin LA also has an early peak and an 8-hour duration of action, with 2 pulses (immediate and after 4 hours)... [Pg.123]

Sustained release formulations (especially Concerta, Metadata CD, and Ritalin LA) should not be chewed but rather should only be swallowed whole... [Pg.123]

Metadate CD and Ritalin LA are somewhat similar to each other, both with an early peak and duration of acfion of abouf 8 hours... [Pg.126]

Metadate CD and Ritalin LA may be preferable for those ADHD patients who lose their appetite for dinner or have insomnia with Concerta... [Pg.126]

In another aspect of the SODAS design, the secondary pellet fraction is produced as described above however, the delayed release beads are produced by coating the IR beads with an enteric polymer (methacrylic acid copolymer) rather than a sustained release polymer (81). This bi-modal release system was used in the formulation of Ritalin LA and was demonstrated to produce two distinct pla.sma concentration peaks separated by approximately 4 hours (81). This bi-modal pulsed release system was demonstrated to be bioequivalent to two immediate release tablet doses administered four hours apart. [Pg.401]

Drug delivery systems of once-daily products (Concerta, Metadate CD, Ritalin LA, Adderall XR) provide 8 to 12 hours of symptom control. Concerta uses an oral osmotic (OROS) controlled-release delivery system, while other preparations use combinations of immediate-release or extended-release beads containing drug. Concerta is a nondeformable tablet and it should not be given to children with gastrointestinal narrowing due to the risk of obstruction. Older wax-matrix sustained-release products (e.g., Ritalin SR)... [Pg.1134]

See other pages where Ritalin LA is mentioned: [Pg.637]    [Pg.638]    [Pg.640]    [Pg.1150]    [Pg.1153]    [Pg.1153]    [Pg.787]    [Pg.449]    [Pg.453]    [Pg.172]    [Pg.184]    [Pg.223]    [Pg.180]    [Pg.342]    [Pg.121]    [Pg.121]    [Pg.1136]    [Pg.1139]    [Pg.342]   
See also in sourсe #XX -- [ Pg.121 ]



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