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Ring systems, importance

Intramolecular 1,4-addition is useful for macrolide synthesis. An unusual molecule of punctaporonin B (272) has been synthesized by this 1,4-addition of 271(160]. Cyclization to form the seventeen-membered ring macrolide 273 was carried out at 0.1-0.5 vi concentration[161. The choice of ligands seems to be important in the macrocyclization. The 26-membered ring model 274 for a synthesis of the ring system of tetrin A was obtained in 92% yield by using triisopropyl phosphite as a ligand[162]. [Pg.326]

Pynmidme and purine themselves do not occur naturally but many of their deriv atives do Before going too far we need to point out an important structural difference between derivatives that bear —OH groups and those with —NH2 groups The struc ture of a pynmidme or punne that bears an —NH2 group follows directly from the struc ture of the parent ring system... [Pg.1156]

If the characteristic group occurs both in a chain and in a cyclic system, the parent is that portion in which the principal group occurs in largest number. If the numbers are the same, that portion is chosen which is considered to be the most important or is the senior ring system. [Pg.20]

Many chemical compounds have been described in the Hterature as fluorescent, and since the 1950s intensive research has yielded many fluorescent compounds that provide a suitable whitening effect however, only a small number of these compounds have found practical uses. Collectively these materials are aromatic or heterocycHc compounds many of them contain condensed ring systems. An important feature of these compounds is the presence of an unintermpted chain of conjugated double bonds, the number of which is dependent on substituents as well as the planarity of the fluorescent part of the molecule. Almost all of these compounds ate derivatives of stilbene [588-59-0] or 4,4 -diaminostilbene biphenyl 5-membeted heterocycles such as triazoles, oxazoles, imidazoles, etc or 6-membeted heterocycles, eg, coumarins, naphthaUmide, t-triazine, etc. [Pg.114]

Phthalocyanines. The pyrrole ring system is also the fundamental stmctural unit of the important group of blue and blue-green pigments known as the phthalocyanines (see Phthalocyanine compounds). [Pg.359]

Hydroisoquinolines. In addition to the ring-closure reactions previously cited, a variety of reduction methods are available for the synthesis of these important ring systems. Lithium aluminum hydride or sodium in Hquid ammonia convert isoquinoline to 1,2-dihydroisoquinoline (175). Further reduction of this intermediate or reduction of isoquinoline with tin and hydrochloric acid, sodium and alcohol, or catalyticaHy using platinum produces... [Pg.398]

The other important carbocycHc ring system used in dyes is naphthalene [91-20-3]. Here the preferred position of attack is the 1-position. However, 2-substituted naphthalenes are thermodynamically more stable, and under equiUbratiag conditions the 2-isomer is formed ia preference to the 1-isomer. [Pg.287]

Examination of the pyrazino[2,3-rf]pyrimidine structure of pteridines reveals two principal pathways for the synthesis of this ring system, namely fusion of a pyrazine ring to a pyrimidine derivative, and annelation of a pyrimidine ring to a suitably substituted pyrazine derivative (equation 76). Since pyrimidines are more easily accessible the former pathway is of major importance. Less important methods include degradations of more complex substances and ring transformations of structurally related bicyclic nitrogen heterocycles. [Pg.309]

Completely trivial names continue in use for good reasons, of which an important one is the need for a simple name for frequent communication concerning a commonly encountered compound or structure. For obscure compounds there is surely neither need nor desirability to perpetuate trivial names, and coining new trivial names is almost never justified. Let us, however, consider purine , the trivial name for what might more systematically be named imidazo[5,4-ring system is so important in biochemistry that exclusive use of one of the systematic names would be intolerable. If the name purine were not available, another short trivial name would inevitably be coined, or even an acronym ( IP or TAP ). It is better to retain the name sanctioned by roughly a century of use, and benefit from a link in comprehension with the past. [Pg.8]

The decalin (bicyclo[4.4.0]decane) ring system provides another important system for study of conformational effects in cyclohexane rings. Equilibration of the cis and trans isomers reveals that the trans isomer is favored by about 2.8 kcal/mol. Note that this represents a change in configuration, not conformation. The energy difference can be analyzed by noting that the cis isomer has three more gauche butane interactions that are... [Pg.142]

Cholesterol is a principal component of animal cell plasma membranes, and much smaller amounts of cholesterol are found in the membranes of intracellular organelles. The relatively rigid fused ring system of cholesterol and the weakly polar alcohol group at the C-3 position have important consequences for the properties of plasma membranes. Cholesterol is also a component of lipoprotein complexes in the blood, and it is one of the constituents oiplaques that form on arterial walls in atherosclerosis. [Pg.255]

The polarity of the C—-OH bond, i.e., the basicity of the carbinol-amine, depends on its structure, particularly on the stability of the ring system (degree of aromatic character), and the electron affinity of the substituents on nitrogen and carbon. Of course, external factors also play an important role in the equilibrium temperature, polarity of the solvent, and presence or absence of catalysts (the solvent can also act as a catalyst). [Pg.170]

Gurnos Jones of the University of Keele, UK covers recent advances in the chemistry of triazolopyridines ring systems, which are of considerable importance in medicinal chemistry, in an update of his 1983 review in Volume 34 of Advances in Heterocyclic Chemistry. [Pg.261]


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See also in sourсe #XX -- [ Pg.208 ]




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