Rickets radiological

Another patient had pain and swelling at the anterior ends of the eighth and ninth ribs (104). This patient had been treated with subcutaneous deferoxamine since the age of 3 years with 37-66 mg/kg/day for 6 days a week. Radiologically there were rickets-like rosary lesions of the costochondral junctions. The pain disappeared within a few days after withdrawal of deferoxamine and reappeared after readministration. The mechanism underlying rickets-like changes due to deferoxamine is not known. 

Metabolic bone disease is a complication usually reported in adults and children receiving long-term home PN. This disorder in adults is characterized by osteomalacia with or without osteoporosis that may present without associated chnical, radiologic, or biochemical abnormalities. The diagnosis may not be made in premature infants until after the development of bone fractures or overt rickets. The etiology is poorly understood and likely multifactorial. Treatment options include pharmacologic intervention, calcimn and vitamin D supplementation, and exercise. Others have recommended removal of vitamin D from the PN in patients with low serum parathyroid hormone and 1,25-hydroxyvitamin D concentrations. ... 

Serum alkaline phosphatase elevation and other indices, both biochemical and radiological, of rickets and osteomalacia are more common in patients receiving anticonvulsant drugs than in control subjects (B13, C16, C37, R16, TIO). The severity of these abnormalities has been reported to relate directly to the duration of therapy (K35, TIO), to the... 

This rare disorder is one of the few conditions in which the diagnosis is made on the basis of low serum alkaline phosphatase activities (R6). It is characterized by radiological and histological features resembling rickets (F18, R6), but differs from the other varieties of rickets by the presence of craniostenosis, dental abnormalities (P16), and the excretion in the urine of abnormal quantities of phosphoethanolamine (F20) and inorganic pyrophosphate (R33). Alkaline phosphatase activities are low in a number of tissues, including the skeleton (Mc3), while the circulating enzyme has the characteristics of intestinal alkaline phosphatase (WIO). 

Biological methods of assay for vitamin D were developed mostly during the period 1930-1945. Details of these basic techniques are well-documented in excellent reviews (Rosenberg, 1945 Bliss and Gyorgy, 1951). These assays are based upon measiu-ement of responses in D-deficient rats or chicks parameters such as prevention or cure of rickets are determined radiologically or by bone ash content. A salient feature about animal assays is the apparent species specificity exhibited by ergocalciferol and cholecalciferol. While the rat responds equally well to both vitamins, on the chick ergocalciferol is only about 3% as effective as cholecalciferol. 

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