Rho guanine nucleotide exchange factor

Prostanoid receptors and their signaling pathways. fMLP, formylated MetLeuPhe, a small peptide receptor PLC-3, phospholipase C-3. All of the receptors shown are of the 7-transmembrane, G-protein coupled type. The terms "relaxant," "contractile," and "inhibitory" refer to the phylogenetic characterization of their primary effects. AII EP3 isoforms couple through G but some can also activate Gs or G12/13 pathways. RhoGEF, rho guanine nucleotide exchange factor. See text for additional details. 

RH-RhoGEF RGS homology Rho guanine nucleotide exchange factor... 

Booden, M. A., Siderovski, D. P., and Der, C. J. (2002). Leukemia-associated Rho guanine nucleotide exchange factor promotes Gaq-coupled activation of RhoA. Mol. Cell. Biol. 22, 4053-4061. 

Fukuhara, S., Chikumi, H., and Gutkind, J. S. (2000). Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G (12) family to Rho. FEBS Lett. 485, 183-188. 

REGULATION OF Rho GUANINE NUCLEOTIDE EXCHANGE FACTORS BY G PROTEINS... 

Eisenhaure, T. M., Francis, S. A., Willison, L. D., Coughlin, S. R., and Lerner, D. J. (2003). The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms. / Biol. Chem. 278, 30975-30984. 

Hirotani, M., Ohoka, Y., Yamamoto, T., Nirasawa, H., Furuyama, T., Kogo, M., Matsuya, T., and Inagaki, S. (2002). Interaction of plexin-Bl with PDZ domain-containing Rho guanine nucleotide exchange factors. Biochem. Biophys. Res. Com-mun. 297, 32-37. 

Jaffe, A. B., Hall, A., and Schmidt, A. (2005). Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho. Curr. Biol. 15, 405-412. 

Kristelly, R., Gao, G., and Tesmer, J. J. (2004). Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. J. Biol. Chem. 279, 47352-47362. 

Park, B., Nguyen, N. T., Dutt, P., Merdek, K. D., Bashar, M., Sterpetti, P., Tosolini, A., Testa, J. R., and Toksoz, D. (2002). Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNALl, supports serum response factor activation. /. Biol. Chem. 277, 45361-45370. 

Pi, M., Spumey, R. F., Tu, Q., Hinson, T., and Quarles, L. D. (2002). Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. Endocrinology 143, 3830—3838. 

Yau, D. M., Yokoyama, N., Goshima, Y., Siddiqui, Z. K., Siddiqui, S. S., and Kozasa, T. (2003). Identification and molecular characterization of the G alphal2-Rho guanine nucleotide exchange factor pathway in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 100, 14748-14753. 

Young, P., Ehler, E., and Gautel, M. (2001). Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly./. Cell. Biol. 154, 123-136. 

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