Rh factor incompatibility

II cytolytic Cell-associated Clonal expansion B cells IgM, IgG generated. Ig binds to cell bound antigen in the presence of complement and/or activated macrophages cell lysis occurs Rh factor incompatability, hemolytic anemeia in reaction to drugs... 

In 1942 Calvin married Genevieve Jemtegaard. After their first child Elin s death, related to Rh factor incompatibility, Calvin and his wife were part of an interdisciplinary project that investigated the etiology of the disease. They helped to determine the composition and structure of the Rh factor, named elinin for their daughter. 

RH Factor Incompatibility. This problem, which is also known as erythroblastosis fetalis, has little to do with nutrition, but it is presented here so that it will not be overlooked by prospective parents. (All obstetricians are well aware of this problem and the appropriate preventive measures, but some American women may have their babies with little or no prenatal advice from a doctor.)... 

The gestational age of the infant is a major factor in the development of neonatal hyperbilirubinemia. The more premature the infant is, the lower the level of expression of the enzymes necessary for synthesis of conjugated bilirubin (discussed in the section on Hepatic Metabolism of Bilirubin) and the more likely the child is to develop jaundice. Babies are not routinely screened for the cause of jaundice until the condition manifests itself. Testing would be instituted early if there were a sibling who had experienced prolonged jaundice, or if the mother is blood type O or is Rh negative. All mothers who have good prenatal care are tested for blood type and Rh antibodies. This alerts the physician to potential problems and allows the physician to anticipate the most common forms of jaundice, namely, ABO incompatibilities. 

Hemolytic Disease. Hemolytic disease in the newborn results from maternal-fetal incompatibility of Rhesus blood factors in which the maternal Rh-negative blood becomes... 

A major complicating factor can be hemolytic anemia such as that of erythroblastosis fetalis caused by Rh incompatibility between mother and child. The hemolysis increases the rate of bilimbin formation, which soon overwhelms the liver and produces severe jaundice and ker-nicterus. Sickle cell anemia has a similar effect. Congenital absence of bilimbin UDP-glucuronyltransferase (Crigler-Najjar syndrome type 1) usually causes a kemictems that is fatal shortly afterbirth. Inhibition of glucuronyltransferase... 

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