Reversible covalent interactions

Can the strategy of combining the sequence specificity of H bond arrays with reversible covalent interactions be extended into polar media To answer this question, strands 3 and 4 were modified with A-trityl end groups capable of reversibly forming disulfide bonds in the presence of iodine (Kamber et al. 1980), leading to complementary strands 19 and 20 (Fig. 9.14a Li et al. 2006). 

There are two general classes of imprinted polymers covalent and noncovalent MlPs. These two categories refer to the types of interactions between the functional monomer and the template in the prepolymerization complex. There are also hybrid MlPs that utilize a combination of covalent and noncovalent interactions in the preparation and rebinding events (Klein et al. 1999). Covalent MlPs utilize reversible covalent interactions to bind the template to the functional monomers. In contrast, noncovalent MlPs rely on weaker noncovalent functional monomer-template interactions. Each type has specific advantages and disadvantages with respect to sensing applications that will be addressed in subsequent sections. 

Although not based on PET designs, 103 [188] strengthens the signaling role played by reversible covalent interactions. Mohr and his colleagues at ETH,... 

The synthesis of MIPs is performed by copolymerization of appropriate monomers in the presence of a template ligand. The monomers interact with the template by non-covalent interactions, reversible covalent interactions, or metal ion-mediated interactions. The types of interactions that are usually exploited in molecular imprinting are as follows ... 

Wulff, G. Dederichs, W. Grotstollen, R. Jupe, C. On the chemistry of binding sites. Part II. Specific binding of substances to polymers by fast and reversible covalent interactions. Anal. Chem. Symp. Ser. 1982. 9, 207-216. (Affinity Chromatogr. Relat. Tech.). 

Taylor MS (2015) Catalysis based on reversible covalent interactions of organoboron compounds. Acc Chem Res 48 295-305... 

The principal idea behind MIP synthesis is the generation of solution state complexes between the template ligand in hand and appropriate functional monomers, followed by subsequent freezing of these complexes by copolymerization of the above with an excess of a cross-linking monomer. These monomer-template complexes are stabilized by non-covalent interactions, reversible covalent interactions, or metal ion-mediated interactions. The types of interactions that are usually exploited in molecular imprinting are 1) cleavable covalent bonds 2) tt-tt interactions 3) hydrogen bonds 4) hydrophobic van der Waals interactions 5) crown-ether/cyclodextrin type interactions 6) metal-Ugand... 

The carbonyl group has always been an important functional group in molecular recognition. It readily reacts with various nucleophiles, among which some are reversible. Along this line, there have been efforts in the development of chemosensors based on reversible covalent interactions between electron-deficient carbonyl groups and different nucleophiles, such as hydroxyl groups. 

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