Resveratrol biological activity

Adrian M, Jeandet P, Veneau J, Weston LA, Bessis R. 1997. Biological activity of resveratrol, a stilbenic compound from grapevines, against Botrytis cinerea, the causal agent for gray mold. J Chem Ecol 23 1689-1702. 

The non-flavonoid phenolic constituents in wine are divided into hydroxybenzoic acids and hydroxycinnamic acids, volatile phenols, stilbenes and miscellaneous compounds (e.g. lignans and coumarins). Although non-colored, the non-flavonoid constituents are known to enhance and stabilize the color of red wines by intra- and intermolecular reactions. They furthermore contribute to wine flavor (volatile phenolic acids) and some of them (e.g. resveratrol) exhibit potent biological activities. 

It is widely accepted that polyphenols in wine are responsible for beneficial health effects (Sun et al. 2006). Particularly fran.y-resveratrol has been intensively studied and marked biological activities with regard to the prevention of cardiovascular disease and cancer have been reported (Ito et al. 2003). Other stilbenes also have properties similar to those of fran.y-resveratrol. Therefore, monitoring new stilbene derivatives in wine is of particular relevance (Guebailia et al. 2006). 

Therefore this present chapter is limited only to discussion on pulse radiolysis studies of promising compounds that exhibit potent biological activities for example, hydroxyl-flavonoids, resveratrol, curcumin, /3-carotene and cyclic nitroxides are reported here. 

Resveratrol [2], 3,4 ,5-trihydroxy-rra/ A-stilbene, is a phytoalexin found in grapes and other plants, that exhibits a variety of biological activities, including antileukemic, antibacterial, antifungal, anti antiplatelet aggregation, coronary vasodilator. Recently, it has been shown to induce apoptosis and decrease expression of Bcl-2 in the human leukaemia HL-60 cell line. 

RESVERATROL OLIGOMERS STRUCTURE, CHEMISTRY, AND BIOLOGICAL ACTIVITY... 

Resveratrol oligomers structure, chemistry, and biological activity 507... 

The plant family Dipterocarpaceae is comprised of three subfamilies, Dipterocarpoideae, Monotoideae, and Pakaraimoideae. Species of the largest subfamily, Dipterocarpoideae, are of most interest because of their economic use in producing timber and oleoresins. Plants of the Dipterocarpoideae are typified as sources of oligostilbenoids (resveratrol oligomers) which have shown various biological activities such as antibacterial, antifungal, anti-HIV antiviral, and cytotoxic effects. This... 

It was shown that treating 5-[2-(4-hydroxyphenyl)vinyl]benzene-l,3-diol (resveratrol) with an equimolar amount of silver(I) acetate in dry MeOH at 50 °C for 1 h, followed by chromatographic purification with a short silica gel column, allowed the isolation of its ( )-dehydrodimer, 5-[5-[2-(3,5-dihydroxyphenyl)vinyl]-2-(4-hydroxyphenyl)-2,3-dihydrobenzofuran-3-yl]benzene-l,3-diol, as a racemic mixture in high yield. The present method was applicable to the oxidative dimerization of 4-hydroxystilbenes such as trows-styrylphenol and 5-[6-hydroxy-2-(4-hydroxyphenyl)-4-[2-(4-hydroxyphenyl)-vinyl]-2,3-dihydrobenzofuran-3-yl]benzene-l,3-diol (epsilon-viniferin) leading to the corresponding 2-(4-hydroxyphenyl)-2,3-dihydrobenzofurans possessing various types of biological activities. 

Many stilbene derivates (stilbenoids) are naturally present in plants. The most widely distributed stilbenoids are resveratrol, combretastatins, and pterostilbene. These agents are derived from terrestrial plants, microorganisms, marine organisms, and animals [1,2]. This chapter is a brief review on diverse biological activities of stilbenes in cells, organs, and animals. 

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