Restenosis model

Hong MK, Komowski R, Bramwell O, et al. Paclitaxel-coated gianturco-roubin II (GR II) stents reduce neointimal hyperplasia in a porcine coronary in-stent restenosis model. Coron Artery Dis 2001 12(6)513-515. 

Kim W, Jeong MH, Cha KS, et al. Effect of anti-oxidant (carvedilol and probucol) loaded stents in a porcine coronary restenosis model. CircJ 2005 69(1) 101-106. 

Verin V Popowski X Urban P et al. Intra-arterial beta irradiation prevents neointimal hyperplasia in a hypercholesterolemic rabbit restenosis model. Circulation 1995 92 2284-2290. 

Belli G, Eccleston MC, Horrigan JG. Locally delivered vascular endothelial growth factor (VEGF) does not inhibit neointimal proliferation in the porcine restenosis model. J Am Coll Cardiol 1997 Abstracts 52A. 

Kipshidze NN, Iversen B Kim HS, etal. Advanced c-myc anti-sense (AVI-4126)-eluting phosphorylcholine-coated stent implantation is associated with complete vascular healing and reduced neointimal formation in the porcine coronary restenosis model. Catheter Cardiovasc Interv 2004 61 (4) 518-527. 

Kipshidze NN, Porter TR, Dangas G, et al. Systemic targeted delivery of antisense with perflourobutane gas microbubble carrier reduced neointimal formation in the porcine coronary restenosis model, Cardiovasc Radiat Med 2003 4(3) 152-159. 

Schwartz, R.S., Chronos, N.A., Virmani, R., 2004. Precfinical restenosis models and drug-eluting stents - sthl important, sthl much to learn. Journal of the American CoUege of Cardiology 44,1373-1385. 

Deux, J.F., Meddahi-Pelle, A., Le Blanche, A.F., Feldman, L.J., Colliec-Jouault, S., Bree, F., Boudghene, F., Michel, J.B., and Letourneur, D. (2002) Low molecular weight fucoidan prevents neointimal hyperplasia in a rabhit iliac artery in-stent restenosis model. Arteriosder. Thromb. Vase. Biol., 22,1604—1609. 

Gonschior, R, Gerheuser, E, Fleuchaus, M., Huehns, T.Y., Goetz,A.E.,Welsch, U., Sroka,R., DeUian, M., Lehr, H.A., and Hofling, B., Local photodynamic therapy reduces tissue hyperplasia in an experimental restenosis model, Photochem. PhotobioL, 64, 758,1996. 

The calcification of atherosclerotic plaques may be induced by osteopontin expression, since osteopontin is a protein with a well-characterized role in bone formation and calcification. Vascular smooth muscle cell migration on osteopontin is dq endent on the integrin av 33 and antagonists of av 33 prevent both smooth muscle cell migration and restenosis in some animal model [8]. 

Restenosis after angioplasty is a situation where these therapies may find an early application. The current animal models evaluate the formation of atherosclerosis or a neointima in the same accelerated and artificially induced... 

Libby P, Shcwartz D, Brogi E, Tanaka H, Clinton S. A cascade model for restenosis. A special case of atherosclerosis progression. Circulation 1992 86 11147-III52. 

A number of animal data supported the use of systemic immunosuppressive therapies in reducing smooth muscle cell growth, the mediator of neointimal proliferation (26,37,38). Preclinical studies have demonstrated a significant reduction of neointimal proliferation after balloon injury in the porcine or rabbits model of restenosis, with the systemic use of rapamycin (26). 

Ahn YK, Jeong MH, Kim JW, et al. Preventive effects of the heparin-coated stent on restenosis in the porcine model. Catheter Cardiovasc Interv I 999 48(3) 324-330. 

Lincoff A, FurstJ, Ellis S, Tuch R, Topol E, Sustained local delivery of dexamethasone by a novel intravascular eluting stent to prevent restenosis in the porcine coronary injury model. J Am Coll Cardiol 1997 29 808-816. 

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