Respiratory quotient human studies

Extending these foregoing studies to the controversial problem of the value of sorbitol in the diabetic diet, Ellis and Krantz carried out typical tolerance tests with the compound. In normal human subjects, 50 g. of sorbitol increased the respiratory quotient above the normal basal level. Within an observation period of two hours, the effect was similar to that produced by an equal quantity of n-glucose. The blood sugar level was not significantly altered by the administration of sorbitol but was markedly elevated by n-glucose. In thirteen moderately severe diabetic... 

Regulation of NADPH Production Fatty Acid Synthase Respiratory Quotient Data from Human Studies... 

RESPIRATORY QUOTIENT DATA FROM HUMAN STUDIES... 

Another goal of the USDA study was to determine whether CLA enhanced energy expenditure, lipolysis, or fat oxidation in humans, similar to the effects observed in animals. Accordingly, measurements of metabolic rate and respiratory quotient were made by indirect calorimetry, and stable isotope tracers of palmitate and glycerol were used to measure the rate of appearance of free fatty acids and glycerol as well as whole body lipolysis and apparent reesterification. CLA supplementation had no effect on metabolic rate or whole-body fat oxidation rate during rest or exercise. Similarly, CLA did not change lipolytic rate, fatty acid release from adipose tissue, or apparent FFA reesterification rates under conditions of rest or exercise (33). 

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