Research protocol

In summary, we demonstrated the possibility of the fast scale-up of solid-phase supported synthesis. In one case (pyrimidine derivate), the research protocols could be used directly with only minor modifica-... 

Human participants are protected from ill-advised research or research protocols in light of both ethical and scientific concerns. 

Intensive instrumental and analytical methods research performed during the 1970 s has clearly contributed to the confidence with which current research results are reported. Examination of recent literature shows that research protocols have departed from simplistic single element studies and have incorporated more realistic experimental designs that include multi-elemental determinations. 

Today, an ethical review is an essential part of the biomedical research process. lECs provide ethical guidance on research protocols and ensure the protection of research participants. In the United States, similar bodies called institutional review boards (IRBs) have a similar role to that undertaken by lECs in the rest of the world. 

The research protocol should always contain a statement of the ethical considerations involved and should indicate that there is compliance with the principles enunciated in this Declaration. 

Chemoinfonnatics, edited by Jiirgen Bajorath, 2004 274. Photosynthesis Research Protocols, edited by... 

Stroke, like myocardial infarction, is a medical emergency. Rapid care by well trained teams in facilities allowing neuroimaging 24 hours a day is the key to better prognosis. Certain drugs have already proven to be beneficial, but much progress remains to be made in developing clinical research protocols. 

The specific policy that sets the standards for federally funded research was revised in 1991 and includes specific policies for research in children (U.S. Department of Health and Human Services [DHHS], 1991a b). The main requirements of the policy include the necessity of having research protocols and consent forms ap-... 

The Belmont Report (24), in considering differences between the research and the clinical setting, noted that departure from commonly accepted drug practice for individual patients should not be considered research. Innovative strategies, however, should be developed in research protocols as quickly as possible to assure safety and efficacy of such a practice. 

Within our review we would like to highlight some selected research protocols for possible AIMD studies of bioinorganic systems, see Section II. In Section II.A we give a very brief introduction to the method as well as some references to useful reviews of the methodology. Next we introduce the research protocols (Section II.B) and after this we show the outcome of such protocols at two selected examples, see Section II.C. Additionally, we shortly introduce at selected examples solvation... 

In this section, we briefly review the tools used by cosmochemists and the datasets that have been acquired over the years. The tools identified below are described in more detail in the Appendix at the end of this book. Drawing on the data gained from these tools and on the intellectual framework of cosmochemistry, we can formulate key questions and define research protocols to answer those questions. Although the datasets and intellectual framework are intimately intertwined, one must always keep in mind that good data always trump theoretical models. 

O Hagan, D.T. (2000). Vaccine Adjuvants Preparation, Methods and Research Protocols, Methods in Molecular Medicine, vol. 35. Humana Press, New York. 

Ulrich JT. MPLr immunostimulant adjuvant formulations. In O Hagan DT, ed. Vaccine Adjuvants Preparation Methods and Research Protocols. Totowa, NJ Humana Press Inc., 2000 273-282. 

Fitzgerald, D. W., A. Wasunna, and J. W. Pape. 2003. Ten Questions Institutional Review Boards Should Ask When Reviewing International Clinical Research Protocols. IRB 25 14—18. 

Maintaining a higher standard (the best proven therapy) will be more expensive. It will slow down research. It will effectively protect only those on the research protocols, just a sample compared to the thousands who might be saved or cured with the implementation of the newly tested drugs or therapies. 

The F.W.G.P.M. Task Force addressed itself mainly to the problem of organophosphates, and its terms of reference were to identify areas in which information on occupational exposure to workers was unavailable, to make recommendations for the development of research protocols to determine safe reentry levels for the protection of agricultural and forest workers, and to suggest interim reentry standards based on existing knowledge. The report was controversial but drew attention to the lack of a substantial data base and to the urgent need for surveillance of pesticide-related morbidity and mortality and for research to identify factors influencing safe worker reentry levels. 

Unfortunately, at least three research protocol features are needed to define the effects of sleep deprivation on athletic performance with any accuracy, (a) The research protocol should isolate the homeostatic from the circadian components as the two so frequently confound each other (3,4). (b) The protocol should include a meaningful competitive event to decrease the chance of motivational confounds and reduce the distortion inherent in extrapolating pieces to a whole (i.e., anaerobic capacity of the quadriceps muscle does not necessarily predict World Cup victory), (c) Finally, the protocol should effectively reduce the myr-... 

Derenzo and Moss (2006) provided a detailed discussion of clinical research protocols, and readers are directed to their book. 

Derenzo, E. and Moss, J., 2006, Writing clinical research protocols Ethical considerations, Elsevier/Academic Press (300 pages, paperback). 

C18. Coronary Drug Project Research Group. The Coronary Drug Project Initial findings leading to modification of its research protocol. J. Am. Med. Assoc. 214, 1303—1313 (1970). 

Grob extolled the desirability of "using these substances in sanctioned, approved clinical settings." He emphasized that the development of research protocols for the use of psychedelics with individuals suffering from extremely refractory conditions—such as post-traumatic stress syndrome, terminal illness, and severe alcoholism—offers the most likely route toward eventually opening the door to more broadly based research. 

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