Reports of Mania, Violence, and Suicide in Adults

Case Reports of Mania, Violence, and Suicide in Adults 

There are many case reports in the scientific literature documenting the capacity of SSRIs to cause mania in adults, often in association with 

Healy et al. (2006) described nine cases in England, Scotland, Australia, and the United States as illustrations of antidepressant-induced violence. Two paroxetine, three sertraline, and one fluoxetine case resulted in homicide. One paroxetine case resulted in assault, one venlafaxine case resulted in attempted murder, and one fluoxetine case resulted in assault and robbery. Some were associated with maniclike symptoms. They also evaluated clinical trial data (see subsequent discussion). 

Severe stimulation reactions were reported in four of six fluoxetine-treated patients with posttraumatic stress disorder, requiring three of them to withdraw from the study Two experienced agitation and worsening of hyperarousal symptoms one patient s panic symptoms markedly 

Mania and hostility frequently go together, and mania is one cause of Prozac-induced violence. Crashing after mania can cause depression and suicide as well. There are many other reports of varying degrees of psychosis caused by Prozac (Chouinard et ah, 1986 Lebegue, 1987 Settle et al., 1984 Turner et al., 1985). LaPorta et al. (1987) described two cases and Mendhekar et al. (2003) described one case of mania caused by Zoloft. 

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