Reporting threshold, definition

The outcome of planning should include the generation of a method definition requirement document (MDRD) in which all stake holders agree, prior to method development, on the critical attributes of the method. Considerations such as what impurities/degradation products should be monitored, requisite reporting thresholds, the need for an MS-compatible method, if identical methods for DP and DS are required, etc., should be clearly decided and agreed upon by all stakeholders. 

Organic acids may exhibit other sensory properties. For example, citric acid possesses sweet-and-sour sensory notes, and succinic acid has a salty-bitter taste. On the other hand, the typical taste and flavor of Emmental cheese can be ascribed to the propionic acid and a few other compounds, such as proline. In fact, taste and flavor result from the combination of different food constituents in definite proportions. Raw meat smells much like lactic acid, which arises from postmortem anaerobic glucolysis and determines the pH of meat, its final properties, and microbial stability. This same organic acid has been related to the inhibition of certain pathogenic bacteria in yogurt (3). Table 1 lists the reported threshold concentrations for various organic acids in different media (4-6). 

As a compromise between the above two approaches, the third approach adopts nonactive (inert) materials as working electrodes with neat electrolyte solutions and is the most widely used voltammetry technique for the characterization of electrolytes for batteries, capacitors, and fuel cells. Its advantage is the absence of the reversible redox processes and passivations that occur with active electrode materials, and therefore, a well-defined onset or threshold current can usually be determined. However, there is still a certain arbitrariness involved in this approach in the definition of onset of decomposition, and disparities often occur for a given electrolyte system when reported by different authors Therefore, caution should be taken when electrochemical stability data from different sources are compared. 

The 1992 Merbs Nathans paper addresses anomalous color vision based on a dichotomy, the possible complete absence of either the L-channel or M-channel chromophores of vision192. Their definition of a complete deutranope as one completely lacking a green, or M-channel, chromophore does not conform to the original definition of the term or as it is used in this work (Section 18.1). No report has been found in either the electrophysiological or psychophysical literature of any sighted human, color-blind or not, who totally lacked an operational M-channel in his visual system. At photopic levels of illumination, the most chromatically limited deutranope exhibits a luminous threshold function within the normal statistical variation of color normals. 

Lagging Metrics—process safety incidents that meet the threshold of severity and shouid be reported as part of the process safety metric Near-Miss Incidents—incidents that did not meet the definition of process safety incident metric... 

Cross-comparison of the three sources is not straightforward. Comparing to observations at the coastal station, for the table in [1] the calculation has been done for the whole sea and authors have evidently put a threshold on very small values of ice concentrations. As a result, the BCh dates of both first ice appearance and of full open water could be later than those observed at in situ coastal stations, where small patches of ice will nevertheless be reported. When comparing satellite estimates and historical observations at the coastal stations it is necessary to bear in mind (a) the difference in methodology of definition of specific ice dates at the coastal stations, and (b) the difference between the size of the region observed from the coast and the much larger lake area observed by satellites [18, 19]. 

Hilsmann (16) found no effect on two-point tactile discrimination, while Kremer (17) recorded a definite increase in the minimal distance for two-point discrimination throughout the surface of the body after 10-15 mg. of morphine was administered subcutaneously. David (11) reported recently that tactile discrimination was decreased in 6 of 10 subjects with 10 mg. (0.14 mg./kg.) and was uniformly decreased in all subjects by 15 mg. (0.22 mg./kg.). Mullin and Luckhardt (18, 19) claimed that tactile sensitivity was not appreciably affected by doses of morphine (35-30 mg.) which reduced sensitivity to pain. Further, according to Wikler et al. (5), the administration of morphine did not alter thresholds of perception for touch, vibration, two-point discrimination, or hearing in man, and hence morphine specifically alters pain thresholds. Wikler felt that this inference was open to question because of the variable effects of analgesics on pain as reported by different investigators (5). 

Rhode (20) reported an immediate increase in the threshold for pain and temperature after 15 mg. of morphine subcutaneously, but touch and pressure sensations were only slightly decreased. Griinthal and Hoefer (21) noted no definite effect on cold and warm sensations after 10 mg. of morphine, but pain and pressure sensations were definitely diminished. 

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