Replication factor

Ataxia telangiectasia mutated (ATM), poly(ADP ribose) polymerase (PARP), DNA-dependent protein kinase, DNA replication factor C, DNA topoisomerase I, DNA fragmentation factor (DFF)45, inhibitor of caspase-activated DNAse (ICAD), lamins A, Bl, and C TRAF-1, Rafl, Ras, GAP, GDP dissociation inhibitor of Rho family GTPases, phospholipase A2, Statl... 

Transitive, iterative searches initiated with the sequences of the anticodon-binding domains of lysyl- and aspartyl-tRNA synthetases provided leads for the identification of biologically interesting, previously unknown OB-fold domains at a statistically significant level (random expectation values <0.01). In particular, OB folds were detected in the eukaryotic replication factor RFA with statistically significant scores this... 

In addition to Sid, Cdc4 targets a number of other important substrates including the replication factor Cdc6, the transcription factor Gcn4 and the... 

GADD45 binds to the replication factor PCNA and inhibits the entry of ceUs into S phase... 

Spann, TR, Moir, R.D., Goldman, A.E., Stick, R. and Goldman, R.D. (1997) Dismption of nuclear lamin organization alters the distribution of replication factors and inhibits DNA synthesis. J. Cell Biol. 136, 1201-1212. 

Roles of Replication Factor C (RFC)- and Proliferating Cell Nuclear Antigen (PCNA)-like Complexes in Damage Sensing... 

Waga S, Bauer G, Stillman B. Reconstitution of complete SV40 DNA replication with purified replication factors. J. Biol. Chem. 1994 269(14) 10923-10934. 

Bermudez VP, Lindsey-Boltz LA, Cesare AJ, Maniwa Y, Griffith JD, Hurwitz J, Sancar A. Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRadl7-replication factor C complex in vitro. Proc. Natl. Acad. Sci. U.S.A. 2003 100(4) 1633-1638. 

Kenna MA Skibbens RV. Mechanical link between cohesion establishment and DNA replication Ctf7p/Ecolp, a cohesion establishment factor, associates with three different replication factor C complexes. Mol. Cell. Biol. 2003 23 2999-3007. 

Nucleotide-excision repair involves PCNA, DNA polymerase epsilon, and several accessory proteins, such as RF-C (replication factor C), RP-A (replication protein A), and Lig I (DNA ligase I). It could be that these proteins form an aggregate DNA repair machine. PCNA is a hollow circular protein that encircles DNA. PCNA binds and activates many proteins involved in DNA repair. Mismatch repair is less well characterized, but involves DNA polymerase delta. 

The catalyst can have a granular or spherical form, it can be tailored to a very high isotactic index, very high extent, quite broad or narrow molecular weight distribution, and so on. The ratio between the average diameter of the flake and the diameter of the catalyst is called the replication factor. 

Examples include the focal adhesion kinase FAK (see Section 11.3), P-catenin (see Section 14.9), p21-activated kinase (PAK), replication factor C, and poly-ADP-ribose polymerase. The latter enzyme participates in the repair of DNA double-strand breaks. 

Method precision (random error, variation) and accuracy (systematic error, mean bias) for LBAs should be evaluated by analyzing validation samples (QC samples) that are prepared in a biological matrix that is judged scientifically to be representative of the anticipated study samples [18]. This topic has been reviewed in other publications [3 6,9,10,20]. These performance characteristics should be evaluated during the method development phase, taking into consideration the factors known to vary in the method (e.g., analysts, instruments, reagents, different days, etc.). Several concentrations are required during the method development phase and are assayed in replicates. Factors known to vary between runs (e.g., analyst, instrument, and day)... 

DNA Replication factor DMA Bindding protefn TranecripHon factor Nuclear hofTrone receptor Unknown Komophlla... 

The primer is extended into daughter-strand DNA by DNA polymerase 8 (Pol 8), which is less likely to make errors during copying of the template strand than is Pol a. Pol 8 forms a complex with Rfc (replication factor C) and PCNA (proliferating cell nuclear antigen), which displaces... 

Green, C. M., Erdjument-Bromage, H., Tempst, P., Lowndes, N. F. (2000). A novel Rad24 checkpoint protein complex closely related to replication factor C. [erratum appears in Curr Biol 2000 Feb 24 10(4) R171]. Current Biology CB, 10, 39—42. 

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