Reoviruses function

The anti-idiotypes in the reovirus system resemble hemagglutinin neutralization domains. Functionally shown here is the consequence of administering monoclonal anti-idiotypic proteins to mice. A variety of reovirus specific immune reactivities are induced. 

Virgin, H. W. I., Mann, M. A., Fields, B. N., and Tyler, K. L. (1991). Monoclonal antibodies to reovirus reveal structure/function relationships between capsid proteins and genetics of susceptibility to antibody action./ Virol. 65, 6772-6781. 

Assembly of reovirus particles in vitro has proved useful for studies of structure-function relationships of viral outer capsid proteins. Particles obtained by mixing baculovirus-expressed cr3 with ISVPs are similar to... 

Given that cap structures are found at the 5 ends of all cellular eukaryotic mRNAs, it is not surprising that they are functionally important in translation initiation. Initial studies using reovirus and vesicular... 

The function of the cap group on mRNAs and presumably, therefore, of the cap recognition proteins has been probed by the construction of mRNAs with altered structures, as well as by analysis of mRNA function in poliovirus-infected cell extracts which lack capbinding activity. Morgan and Shatkin (1980) and Kozak (1980a,ft) prepared reovirus mRNAs with reduced secondary structure by sub-... 

The observation that irradiation of reassortant viruses did not impair their effect on host cell DNA synthesis extends the studies of Shaw and Cox (1973), who found that UV irradiation of reovirus did not abolish the inhibitory effect on host DNA synthesis, suggesting that either a component of the virus is capable of causing inhibition or that ribonucleic acid can function after inhibition to give rise to an inhibitory component. Possibly, an initial al protein-cell interaction could exert the inhibitory effect. Alternatively, the transcription of... 

Reovirus infection not only produces a disruption of intermediate filaments, but also leads to a disorganization of mitochondrial distribution (Sharpe et al., 1982). Vizualized with the fluorescent probe Rhodamine 123 (Johnson et al., 1980 Walsh et al., 1979), mitochondria have a characteristic discontinuous distribution in the CV-1 cell cytoplasm. Reovirus infections result in the aggregation of mitochondria around the nucleus with only occasional mitochondria present at the cell periphery. Mitochondria are not present within viral inclusions. Although reovirus infection affects mitrochondrial distribution, whether reovirus infection alters mitochondrial function is uncertain. Johnson et al. (1981) showed that the accumulation of Rhodamine 123 by mitochondria reflects the transmembrane potential. The accumulation of Rhodamine 123 is similar in infected and unin-... 

Chaly, N., Johnstone, M., and Hand, R., 1980, Alterations in nuclear structure and function in reovirus-infected cells, Clin. Invest. Med. 2 141. 

Silverstein, S. C., and Dales, S., 1968, The penetration of reovirus RNA and initiation of its genetic function in L-strain fibroblasts, J. Cell. Biol. 36 197. 

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