Relationships between partitioning

Hansch, C., Quinlan, J. E., Lawrence, G. L. The linear free-energy relationship between partition coefficients and the aqueous solubility of organic liquids. 

Hawker, D.W., Connell, D.W. (1985) Relationships between partition coefficient, uptake rate constant, clearance rate constant and time to equilibration for bioaccumulation. Chemosphere 14, 1205-1219. 

This excursion into models suggests that the random walk process in itself is unlikely to lead to parabolic relationships between partition coefficient and toxicity... 

Figure 11.11 Thermodynamic relationship between partitioning free energies and free energies of solvation. Knowledge of any two free energies permits prediction of the third since any cycle around the free-energy triangle must sum to zero...

Hansch, C., J.E. Quinlan, and G.L. Lawrence. 1968. The Linear Free Energy Relationships Between Partition Coefficients and the Aqueous Solubility of Organic Liquids. J. Org. Chem. 33 347-350. 

Relationship between partition coefficients and solubility coefficients... 

The relationship between partitioning and free energy of melting can be seen by considering the equilibrium constant ... 

Leo, A. and Hansch, C. (1971a). Linear Free-Energy Relationships Between Partitioning Solvent Systems. J.Org.Chem., 36,1539-1544. 

Takacs-Novak K, Nagy P, Jozan M, Orfi L, Dunn WJ 3rd, Szasz G. Relationship between partitioning properties and (calculated) molecular surface. SPR investigation of imidazoquina-zolone derivatives. Acta Pharm Hung 1992 Jan-Feb 62(l-2) 55-64. 

Since the lipophilic character was found important for physiological dispositions of barbiturates, several workers investigated the relationship between partition coefficient and structural parameters (Taft s polar and steric substituents constants, number of C-atoms) of these compounds.548,549 Partitioning of barbiturates was also proved to be a significant factor for their... 

Based on correlations of pKa values and lipophilicity data, it appears that compounds with a log D (the sum of the partition coefficients of both the ionized and unionized species) near 1.0 60.5 at pFI 7.4 are most efficacious, and their water-soluble salts also show a low incidence of ocular irritation. Relationships between partitioning characteristics of these and other antihistamines indicate (at least moderate) receptor affinity and that a particular range of optimal lipophilicity for topical ocular antihistamines with minimal ocular irritation (43). Some of these compounds are currently available (Table 37.9) or are being evaluated as nasal sprays, and some also are occasionally used as systemic antihistamines. 

Relationships Between Partition Coejficients in Different Solvents... 

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