Solvent systems, hydrophilic relationships between partitioning

Meanwhile attention was drawn to the overriding importance of a physical property when, at the turn of the present century, Overton and Meyer independently put forward a Lipoid Theory of Cellular Depression (Meyer, 1899 Overton, 1901). This stated that chemically inert substances, of widely different molecular structures, exert depressant properties on those cells (particularly those of the central nervous system) that are rich in lipids and that the higher the partition coefficient (between any lipid solvent and water) the greater the depressant action. This statement requires only insertion of the words, up to the point where hydrophilic properties are almost extinguished after partition coefficient to outline the present day viewpoint. It is now appreciated that the relationship between lipophilicity and depression of nerve functioning is a parabolic one, because substances that are entirely lipophilic become trapped in other lipids and do not enter the cell (Hansch et al., 1968). Table 2.1 offers... 

The organic carbon-water partition coefficient is a compound-specific term that allows the user to estimate the mobility of a solvent in saturated-soil water systems if the amount or organic carbon is known. For hydrophilic solvents, values have been measured for many compounds. Other values were derived from empirical relationships drawn between water solubility or octanol-water partition coefficients. ... 

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See also in sourсe #XX -- [ ]

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