Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Regulation of Receptor Activity

A physiologically important aspect of signal transmission via transmembrane receptors is its regulation. The cell has various mechanisms available, with the help of which the number and activity of transmembrane receptors can be regulated. The aim of [Pg.186]

Targeted degradation of transmembrane receptors is another means of regulating receptor activity. Signals for ubiquitination and subsequent degradation in the protea-some have been identified in the cytosolic domain of transmembrane receptors. [Pg.187]


The cytosohc domain thus carries sequences important for short-term or long-term regulation of receptor activity. [Pg.181]

LRP4 is another receptor of the LDL receptor gene family involved in regulation of embryonic patterning, mainly controlling formation of limb structures. Loss of receptor activity in gene targeted mice or spontaneous mutation in bovine cause abnormal limb development and... [Pg.707]

The regulation of receptor synthesis is a second component of receptor downregulation. It involves processes that reduce gene transcription, mRNA stability, and receptor half-life time. It should be noted that mechanisms in addition to the regulation of the receptor number may account for tolerance development. Second messenger levels and enzyme activities that participate in the signaling of a given receptor are... [Pg.1206]

Drew, A.E., Derbez, A.E., and Werling, L.L., Nicotinic receptor-mediated regulation of transporter activity in the rat prefrontal cortex, Synapse, 38, 10, 2000. [Pg.19]

Palmqvist P, Persson E, Conaway HH, Lerner UH (2002) IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae. J Immunol 169 3353-3362... [Pg.195]

Shenoy, S. K., et al.. Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science, 2001,... [Pg.99]

The biologically inactive estrone sulfate (EIS) and dehydro-epiandrosterone-sulfate (DHEAS) are the most abundant circulating estrogenic precursors in the plasma of post-menopausal women [103]. Desulfation of inactive steroid-3-0-sulfates by estrone-sulfatase (STS) plays a key role in the regulation of levels of receptor-active estrogenic steroids (estradiol and androstenediol) in breast cancer cells (Fig. 9). There is strong evidence suggesting that estrone sulfatase (STS) and DHEA-sulfatase are the same enzyme [103]. [Pg.43]


See other pages where Regulation of Receptor Activity is mentioned: [Pg.794]    [Pg.467]    [Pg.180]    [Pg.180]    [Pg.184]    [Pg.42]    [Pg.794]    [Pg.31]    [Pg.186]    [Pg.187]    [Pg.192]    [Pg.952]    [Pg.15]    [Pg.442]    [Pg.445]    [Pg.794]    [Pg.467]    [Pg.180]    [Pg.180]    [Pg.184]    [Pg.42]    [Pg.794]    [Pg.31]    [Pg.186]    [Pg.187]    [Pg.192]    [Pg.952]    [Pg.15]    [Pg.442]    [Pg.445]    [Pg.186]    [Pg.312]    [Pg.488]    [Pg.848]    [Pg.929]    [Pg.1002]    [Pg.10]    [Pg.4]    [Pg.235]    [Pg.380]    [Pg.99]    [Pg.238]    [Pg.239]    [Pg.257]    [Pg.420]    [Pg.25]    [Pg.52]    [Pg.253]    [Pg.386]    [Pg.93]    [Pg.188]    [Pg.195]    [Pg.277]    [Pg.231]    [Pg.313]    [Pg.258]    [Pg.24]   


SEARCH



Activation of receptors

Active receptor

Receptor activation

Receptor activities, regulation

Receptor activity

Receptor regulation

© 2024 chempedia.info