Regulation of Biosynthesis

Demain AL, Vaishnav P. (2003) Nitrogen regulation of biosynthesis of antibiotics and other secondary metabolic products. Pharma Chem 2(10) 92-96. 

Relatively recently Fe/S proteins have been found to function in the regulation of biosynthesis. This can be by promoting deoxyribonucleic acid (DNA) transcription, e.g. the [2Fe-2S] containing Escherichia coli superoxide-activated (SoxR) transcription activator [10-12], or the presumably [4Fe-4S]-containing E. coli transcription factor fumarate nitrate reduction (FNR) [13,14], Alternatively, the Fe/S protein can act by interference with messenger ribonucleic acid (mRNA) translation, i.e., the iron regulatory proteins (IRPs) [15,16], These interactions are stoichiometric, therefore not catalytic. Presumably, they are also a form of sensoring, namely, of oxidants and/or iron [17],... 

Gillespie, J. M. (1983). The structural proteins of hair isolation, characterisation, and regulation of biosynthesis, in Biochemistry and Physiology of the Skin (L. A. Goldsmith, Ed.). Oxford Oxford University Press, 475-510. 

Role of endocrine and physiological factors in regulation of biosynthesis and transport in social insects... 

Martin JF, Aharonowitz Y (1983) Regulation of biosynthesis of (5-lactam antibiotics, pp 229-254. In Demain AL, Solomon NA (eds) Antibiotics containing the P-lactam structure, Part I. Springer, Berlin Heidelberg New York... 

Structure-activity relationship Biosynthesis and Metabolism Biosynthesis of castasterone Biosynthesis of brassinolide from castasterone Regulation of biosynthesis Metabolism and its regulation Physiology and Signal Transduction Physiology Signal transduction Jasmonates and Oxylipins Introduction Chemistry Chemical structure Chemical stability... 

Cary JW, Bhatnagar D, Linz JE Aflatoxin Biological significance and regulation of biosynthesis in Cary JW, Linz JE, Bhatnagar D (eds) Microbial Foodbome Diseases. Mechanism of pathogenesis and toxin synthesis. Lancaster, Technomic Publishing, 2000, pp 317-361. 

The most important information concerning mechanisms of regulation of cholesterol 7a-hydroxylase is summarized in the model shown in Fig. 14. In view of the importance of HMG-CoA reductase for cholesterol 7a-hydroxylase activity, some important modulators of HMG-CoA reductase activity have also been included (cf. Chapter 2). It should be pointed out that the regulation of biosynthesis of cholesterol shown in Fig. 14 is oversimplified. For a discussion of the regulation of HMG-CoA reductase, the reader is referred to Chapter 2 and a recent review by Brown and Goldstein [246]. 

Pyrimidines play a central role in cellular regulation and metabolism. They are substrates for DNA and RNA biosynthesis, regulators of biosynthesis of some amino acids, and cofactors in the biosynthesis of phospholipids, glycolipids, sugars, and polysaccharides (17B45). Pyrimidine biosynthesis is very complicated and involves formic acid, glutamate, and aspartate as starting materials in a series of enzymatic reactions to eventually form orotic acid. Orotic acid, or uracil-... 

Theze, J. Kleidman, L. Saint Girons, L Homoserine kinase from Escherichia coli K-12 properties, inhibition by L-threonine, and regulation of biosynthesis. J. Bacteriol., 118, 577-581 (1974)... 

Adamcova J, Proksa B, Fuska J (1992) Regulation of biosynthesis of vermiculin and ver-mistatin in Penicillium vermiculatum. Folia Microbiol 37 50-52... 

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