Regulation of Glutathione Biosynthesis

Through the action of y-glutamylcysteine synthetase (GLC) and glutathione synthetase (GS), GSH can be synthesized in the cytosol of most mammalian cells. 

6 GLUTATHIONE/GLUTATHIONYLATION DEPENDENT SIGNALING SYSTEMS AND ANTIOXIDANT DEFENSE 

Protein thiols can interact with glutathione by several mechanisms that permit glu-tathionylation to participate in the regulation and antioxidant protection of specific protein thiols. These reactions are involved in the consequences of oxidative stress caused by reactive species of oxygen and nitrogen and include the formation of protein sulfenic acids and their participation in regulatory processes. 

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Shih, A.Y., Johnson, D.A., Wong, G., Kraft, A.D., Jiang, L., Erb, H., Johnson, J.A., et al. 2003. Coordinate Regulation of Glutathione Biosynthesis and Release by Nrl2-Expressing Glia Potently Protects Neurons from Oxidative Stress, 23(8), 3394-3406. 

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