Regional variations, in percutaneous

Wester, R.C. and H.I. Maibach (1989). Regional variation in percutaneous absorption, in Percutaneous Absorption Mechanisms, Methodology, Drug Delivery, 2nd Edn, R.L. Bronaugh and H.I. Maibach (Eds), Marcel Dekker, New York, pp. III-I20. 

Maibach, H.I., Feldman, R.J., Milby, T.H., Serat, W.F. (1971). Regional variation in percutaneous penetration in man. Pesticides. Arch. Environ. Health 23 208-11. 

Regional variations in percutaneous absorption contribute to differences in the systemic availability of a drug depending on the site of topical application. The Rhesus monkey Macaca mulatta) could probably serve as an animal model for human skin regional variation.f ° ... 

Regional variations in percutaneous absorption contribute to differences in the systemic availability of a drug depending on the site of topical application. 

Environmental Protection Agency (1982) Pesticides registrations proposed data requirements. Sec. 158.135 toxicology data requirements. Federal Regulations 47 53192 Feldman RJ, Maibach HI (1967) Regional variation in percutaneous penetration of [ " C] cortisone in man. J Invest Dermatol 48 181-183... 

Large regional variations in percutaneous absorption of compounds are determined by factors including hair follicle density, thickness of the stratum corneum, and vasculature of the region [13]. There is a distinct difference in the penetration of hydrocortisone in different anatomic sites. This suggests that for areas of higher penetrability, such as the face, scalp, scrotum, axilla, and the groin, smaller doses are required and occlusion is not needed [22]. 

Feldmann RJ, Maibach HI (1967) Regional variation in percutaneous penetration of " C cortisol in man. J Invest Dermatol 48 181-183... 

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