Receptors phosphoinositide-linked

Reid SNM, Romano C, Hughes T, Daw NW (1995) Immunohistochemical study of two phosphoinositide-linked metabotropic glutamate receptors (mGluRla and mGluR5) in the cat visual cortex before, during, and after the peak of the critical period for eye-specific connections. J Comp Neurol 355 410-411. 

ACPD receptors are linked by G-proteins to the phosphoinositide-protein kinase C (PI-PKC) and adenylate cyclase-cyclic AMP second messenger systems (Conn and Desai, 1991 Winder and Conn, 1992). Actions on the PI system promote the release of Ca from intracellular stores (Conn and Desai, 1991). The most selective agonist for ACPD receptors is lS,3R-trans-ACPD, although Glu, ibotenate and Quis also act at these receptors. A related class of metabotropic receptors is activated by APB. Seven different metabotropic Glu receptors (mGluRl-7) have been cloned to date (Hollmann and Heinemann, 1994 Saugstad et al.,... 

Fotuhi M, Sharp AH, Glatt CE, et al. Differential localization of phosphoinositide-linked metabotropic glutamate receptor (mGluRl) and the inositol 1,4,5-trisphosphate receptor in rat brain. / Neurosci. 1993 13(5) 2001-2012. 

H linked intracellular messengers. Activated H receptors are known to activate a pertussis-toxin-insensitive G protein, Gq, that stimulates phosphoinositide-specific phospholipase C (PI-PLC), with the subsequent generation of inositol 1,4,5-trisphosphate (IP3) and diacylglyc-erol (DAG). These two mediators are known to elevate intracellular Ca2+ concentrations and to activate PKC,... 

Sagales T, Erill S, Domino EF. (1975). Effects of repeated doses of scopolamine on the electroencephalographic stages of sleep in normal volunteers. Clin Pharmacol Ther. 18(06) ITJ-yi. Sanders-Bush E, Burris KD, Knoth K. (1988). Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis. J Pharmacol Exp Ther. 246(3) 924-28. 

Sanders-Bush E, Burris KD, Knoth K. Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis. J Pharmacol Exp Ther 1988 246 924-928. 

The next step in the transduction process is more problematical. On the one hand, evidence has been adduced indicating that the ETR protein interacts directly with the CTRl protein kinase [64], On the other hand the rapid effects of ethylene on the activation of SMG proteins suggests that these may play a role in linking the receptor to Raf or other protein phosphorylation cascades, as in the case in animals [65-68], The possible role of such proteins is in itself complex since they may not only control pathways separate from protein phosphorylation cascades (e.g. phosphoinositides [69,70] but may themselves interact via GTPase cascades [71]. Equally, it is important to mention that the small GTP-binding proteins constitute a superfamily, the various members of which may have very different functions [72-77]. In neither Arabidopsis [60] nor in peas [59] is it yet clear which member(s) of the superfamily are activated. 

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