Receptors inbred mice

Autoimmune deficiency disease Arylhydrocarbon hydroxylase receptor in humans and mice, respectively Acute promyelocytic leukemia All trans retinoic acid A member of the nuclear receptor family An inbred mouse strain An inbred mouse strain HIV receptor... 

Stevens KE, Freedman R, Collins AC, et al. Genetic correlation of inhibitory gating of hippocampal auditory evoked response and alpha-bungarotoxin-binding nicotinic cholinergic receptors in inbred mouse strains. Neuropsychopharmacology 1996 15 152-162. 

Over the next 30 years, two lines of evidence led to the identification of the AHR, the protein that functioned as the PAH sensor and regulated AHH activity. The first indications that such a receptor existed came from genetic studies of inbred mouse strains. Early studies demonstrated that C57BL/6 mice were much more responsive... 

The remarkable potency of TCDD in eliciting its toxic effects in animals suggested the possible existence of a receptor for dioxin [167]. Biochemical and genetic evidence implicates the TCDD-receptor in the biological responses to dioxin-like compounds. Electrophoretic studies to evaluate the properties of specific proteins from inbred mouse strains reveal the existence of several forms of the TCDD-binding protein [168]. These observations imply the existence of multiple alleles at the Ah locus in mice [169], The biochemical properties of the different forms of the Ah receptor remain to be described. 

The evidence to date implies that the Ah receptor participates in every biological response to TCDD. For example, studies of stmeture activity relationships among congeners of TCDD reveal a correlation between a compound s specific binding affinity and its potency in eliciting biochemical responses, such as enzyme induction [171]. Furthermore, inbred mouse strains in which TCDD binds with lower affinity to the receptor exhibit decreased sensitivity to dioxin s biological effects, such as thymic involution, cleft palate formation, and hepatic porphyria. While there are a few... 

Stalvey, J. R. D., and Payne, A. H., 1983, Luteinizing hormone receptors and testosterone production in whole testes and purified Leydig cells from the mouse Differences among inbred strains. Endocrinology, 112 1696. 

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