Receptors dynamics

Cameron, H. A. and Gould, E. The control of neuronal birth and survival. In Receptor Dynamics in Neural Development (1st edn). Ed. Shaw, C. A. New York CRC Press, 1996, ppl41-157. 

Buranda, T., Jones, G., Nolan, J., Keij, J., Lopez, G. P., and Sklar, L. A. (1999). Ligand receptor dynamics at streptavidin coated particle surfaces A flow cytometric and spectrofluorimetric study. / Phys. Chem. B. 103, 3399-3410. 

Steinbrecht R. A. (1999) Olfactory receptors. In Atlas of Arthropod Sensory Receptors, Dynamic Morphology in Relation to Function, eds E. Eguchi and Y. Tominaga. Springer-Verlag, Tokyo. 

Shi, S.-H. 2001. Essay Amersham Biosciences and Science Prize AMPA Receptor Dynamics and Synaptic Plasticity. Science 294,1851-1852. 

Akaaboune M, Grady RM, Turney S, Sanes JR, Lichtman JW. Neurotransmitter receptor dynamics studied in vivo by reversible photo-unbinding of fluorescent ligands. Neuron 2002 34 865-876... 

As shown in Figure 19.3E (inside the dotted square), the drug kinetics and receptor dynamics were modeled with the differential equations as follows ... 

The drug kinetics and receptor dynamics were modeled as before (Section 19.2.1). As depicted in Figure 19.5A, a mechanistic model was proposed to describe the simultaneous actions of CS on PEPCK mRNA synthesis and degradation, induction of cAMP by CS, and translational stimulation by cAMP ... 

FIGURE 23.7 Schematic of a time-dependent transduction model with three transit compartments (Mi) characterized by a mean transit time (t). The production of the drug-receptor complex RC) initiates the PD cascade and a linear transducer function E and Eq. (23.20)) may be substituted for RC in the absence of specific receptor dynamics. 

In this chapter we summarize some aspects of the structure-functional relationship of the ala and alb-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor. Molecular modeling of the ala and alb-adrenergic receptor subtypes and computational simulation of receptor dynamics were useful to interpret the experimental findings derived from site directed mutagenesis studies. 2000 Elsevier Science B.V. All rights reserved. 

Adams, T.E., S. Gumming B.M. Adams. 1986. Gonadotropin-releasing hormone (GnRH) receptor dynamics and gonadotrope responsiveness during and after continuous GnRH stimulation. Biol. Reprod. 35 881-9. 

Some pathophysiological states are characterized by perturbations in receptor dynamics. Prinzmetal s angina is thought to be characterized by an imbalance between vasodilatory P2-adrenoceptor function and vasoconstrictor -adrenoceptor function. In this disease state, the excessive alpha vasoconstriction of... 

Adams, J.A., Omann, G.M. and Linderman, J.J. (1998). A mathematical model for Ugand/receptor dynamics and actin polymerization in human neutrophils.y. Theor. Biol. 193, 543-560. 

Hoffman, J.F., Linderman, J.J., Omann, G.M. (1996). Receptor upregulation, internalization, and interconverting receptor states critical components of a quantitative description of N-formyl peptide-receptor dynamics in the neutrophil. /. Biol. Chem. 271, 18394-18404. 

SWar, L.A., Hyslop, P.A., Oades, Z.G., Omann, G.M., Jesaitis, A.J., Painter, R.G. and Cochrane, C.G. (1985). Signal transduction and hgand-receptor dynamics in the human neutrophil. Transient responses and occupancy-response relations at the formyl peptide receptor. J. Biol. Chem. 260, 11461—11467. 

SWar, L.A. (1987). Real-time spectroscopic analysis of ligand-receptor dynamics. Annu. Rev. Biophys. Biophys. Chem. 16, 479—506. 

Visser, A. J, W. G., van Hoek, A., and van Paridon, P. A, 1987, Time-resolved fluorescence depolarization studies of parinaroyl phosphatidylcholine in Triton X>100 micelles and rat skeletal muscle membranes, in Membrane Receptors. Dynamics, and Energetics, K. W, A, Wirtz (ed.). Plenum Press, New York, pp. 353-361. 

Zhang, J., Chalmers, M.J., Stayrook, K.R., et al. (2010) Hydrogen/deuteiium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer. Structure, 18 (10), 1332-1341. 

De Boer AH, Lomax TL, Sandstrom RP, Cleland RE (1987) In Wirtz KWA (ed) Membrane receptors, dynamics, and energetics. Plenum New York, p 181... 

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