Receptor dynamic nature

In contrast to the rapid changes upon receptor activation in intracellular concentrations of lower inositol polyphosphates (e.g., Ins(l,4,5)P3), InsPe concentrations seem immutable. This finding, along with observations of the sluggish incorporation of radiolabeled inositol into InsPe, prompted interpretations of slow turnover rates for InsPe in vivo. However, the identification of InsPe as a precursor to even more phosphorylated inositol polyphosphates overturned these misconceptions and revealed the true dynamic nature of cellular InsPe. 

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