Receptors combinatorial libraries

Park SI, Renil M, Vikstrom B et al (2002) The use of one-bead one-compound combinatorial library method to identify peptide ligands for cz4f31 integrin receptor in non-Hodgkin s lymphoma. Lett Pept Sci 8 171-178... 

Scheme 40 Synthesis of receptor 80-S-S-80 from a dynamic combinatorial library based on 80-SH and 81-SH. The receptor is amplified in the presence of a tripeptide template...

Otto S, Severin K (2007) Dynamic Combinatorial Libraries for the Development of Synthetic Receptors and Sensors. 277 267-288... 

Guo, T. and Hobbs, D.W. Privileged structure-based combinatorial libraries targeting G protein-coupled receptors. Assay Drug Dev. Tech. 2003, 1, 579-592. 

Still, W. C. Discovery of sequence-selective peptide binding by synthetic receptors using encoded combinatorial libraries. Acc. Chem. Res. 1996,29,155-163. 

Ludlow, R. F. Otto, S. Two-vial, LC-MS identification of ephedrine receptors from a solution-phase dynamic combinatorial library of over 9000 components. J. Am. Chem. Soc. 2008,130, 12218-12219. 

Corbett, P. T Sanders, J. K. M. Otto, S. Exploring the relation between amplification and binding in dynamic combinatorial libraries of macrocyclic synthetic receptors in water. Chem. Eur. J. 2008,14, 2153-2166. 

Corbett, A. D. Cheeseman, J. D. Kazlauskas, R. J. Gleason, J. L. Pseudodynamic combinatorial libraries A receptor-assisted approach for drug discovery. Angew. Chem. Int. Ed. 2004,43, 2432-2436. 

Another example in which literature results were reanalyzed in view of the PSSC concept concerns the development of ligands for the farnesoid X receptor. The farnesoid X receptor is a transcriptional sensor for bile acids, the primary products of cholesterol metabolism, and plays an important role in lipid homeostasis. The farnesoid X receptor was, until recently, an orphan receptor, which means that no specific ligands existed for this receptor. Selective ligands for this receptor have been found in natural product libraries described by Nicolaou et al. The group of Nicolaou developed solid phase synthesis methods to make combinatorial libraries based on a benzopyran core structure. " A 10,000-membered combinatorial library based on the benzopyran core structure was synthesized and screened for activity on the farnesoid X receptor. The first specific ligands for the... 

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