Tyrosine kinase antagonists receptor

VEGF receptor blockers Small receptor tyrosine kinase antagonists... 

I. VEGF Receptor Tyrosine Kinase Antagonist Assay... 

VEGF receptor tyrosine kinase antagonist assay was performed according to the method of Shibuya (1). Testing results are provided in Table 3. 

Table 3 Effectiveness of selected experimental agents as Flt-1 VEGF receptor tyrosine kinase antagonists. IC50 values above 0.01 p,M are preferred...

Additional benzamide VEGF receptor tyrosine kinase antagonists prepared by the authors (2) in an earlier investigation are summarized in Table 4. 

Andrews (3) and Tang (4) prepared VEGF receptor tyrosine kinase antagonists consisting of l,3-dihydro-2H-indol-2-one derivatives, (I) and (II), respectively, which were effective as abnormal cell proliferation inhibitors. 

Antagonists of Receptor Tyrosine Kinases Enhance Therapeutic Response to Radiation Endothelial Repair Gene Therapy Approach to Angiolytic and Angiostatic Therapy in Cancer References... 

ANTAGONISTS OF RECEPTOR TYROSINE KINASES ENHANCE THERAPEUTIC RESPONSE TO RADIATION... 

The metalloprotease carboxypeptidase catalyses the removal of C-terminal residues and is structurally related to the PM-located epidermal growth factor (EGF) receptor tyrosine kinase (see Chapter 8). Several plant carboxypeptidase inhibitor proteins have been characterized and the potato carboxypeptidase inhibitor (PCI) is also an EGF receptor antagonist (Table 13.4). 

Pandey, A., Volkots, D. L., Seroogy, J. M. etal. Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase family. J. Med. Chem. 2002, 45, 3772-3793. 

Researchers Identified the transcription factors downstream from TGFp receptors In Drosophila from genetic studies similar to those used to dissect receptor tyrosine kinase pathways (see Section 14.3). These transcription factors in Drosophila and the related vertebrate proteins are now called Smads. Three types of Smad proteins function in the TGFp signaling pathway receptor-regulated Smads (R-Smads), co-Smads, and Inhibitory or antagonistic Smads (TSmads). 

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