Receptor promiscuous

The functionality that is often necessary for a chiral crown ether to serve a particular purpose can usually be introduced by the synthetic chemist without too much difficulty. The practice here, however, can be very much more demanding on account of the promiscuous receptor properties of the compounds that have to be separated and isolated pure from reaction mixtures containing many components. 

Kostenis, E., Zeng, F. Y., and Wess, J. (1998). Functional characterization of a series of mutant G protein aq subunits displaying promiscuous receptor coupling properties./. Biol. Chem. 273, 17886-17892. 

Several kinds of structures able to receive functional signals of CK are known. The most important ones can be formed into the following categories (1) specific receptors, (2) shared receptors, (3) promiscuous receptors, (4) virally encoded receptors, and (5) orphan receptors. ... 

The platelet activating factor receptor as a GPCR (rhodopsin family) is possibly also a promiscuous receptor for CKs. The same can be considered for the chemoattractant receptors, complement 5 anaphylatoxin receptor, and FPR/FMLPR (N-formyl peptide receptor). 

Lipophilic ligand efficiency (LLE) is a more recent concept than LE and has been implicated in toxicity resulting from promiscuous receptor interactions, which are driven mainly by lipophilicity. It was proposed" that LLE values of... 

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