Central nervous system receptor properties

Monaghan, D. T., Bridges, R. J. Cotman, C. W. (1989). The excitatory amino acid receptors their classes, pharmacology and distinct properties in the function of the central nervous system. A Rev. Pharmacol Toxicol. 29, 365-402. 

Spano, P. F., Govoni, S., and Trabucchi, M. (1978) Studies on the pharmacological properties of dopamine receptors in various areas of the central nervous system. Adv. Biochem. Psychopharmacol. 19, 155-165. 

MecfMtiism of Action A BZ-1 receptor selective benzodiazepine with sedative properties. Therapeutic Effect Produces sedative effect from its central nervous system (CNS) depressant action. 

This chapter will review the characteristics and regulatory properties of a2 receptors, neuropharmacology of the a2-adrenergic agonists, hypothesized mechanisms by which these medications alter central nervous system (CNS) activity, as well as a variety of issues related to their clinical use, including safety and adverse effects, dosing, and medication interactions. 

Is a central nervous system (CNS) dopamine-receptor antagonist Has cholinomimetic properties Has sedative properties... 

Opioid alkaloids (eg, morphine) produce analgesia through actions at receptors in the central nervous system (CNS) that contain peptides with opioid-like pharmacologic properties. The general term currently used for these endogenous substances is endogenous opioid peptides. 

The binding sites for benzodiazepines are divided into central and peripheral types. The central or neuronal benzodiazepine receptors are influenced by GABA, linked to chloride channel, and responsible for mediating the anxiolytic, sedative, and anticonvulsant properties of the benzodiazepines. The peripheral or nonneuronal benzodiazepine receptors are found in a variety of tissues, including the kidney, heart, lung, liver, adrenal gland, testis, intestinal smooth muscles, mast cells, platelets, several cell lines, and nonneuronal elements in the central nervous system (CNS). 

There is little information about the toxicity of 2C-B as there are only a limited number of studies done on the drug. However, some conclusions can be draw about its physiological effects based on studies of drugs that are chemically similar to 2C-B. The drug binds to serotonin receptors in the brain, which is why it has hallucinogenic properties. Serotonin is a neurotransmitter or messenger substance that carries information through the peripheral and central nervous systems. 

In animals, adrenomedullin dilates resistance vessels in the kidney, brain, lung, hind limbs, and mesentery, resulting in a marked, long-lasting hypotension. The hypotension in turn causes reflex increases in heart rate and cardiac output. Adrenomedullin also acts on the kidneys to increase sodium excretion, and exerts several endocrine effects including inhibition of aldosterone and insulin secretion. Finally it acts on the central nervous system to increase sympathetic outflow. These diverse actions of adrenomedullin are mediated both by CGRP receptors and unique adrenomedullin receptors, the properties of which are incompletely defined. The major second messenger for both receptors is cAMP. 

The recognition that dopamine (DA) Is an important neurotransmitter with receptors in both the central nervous system and in the periphery has resulted in a widespread search for substances that either mimic or block the action of this natural neurotransmitter on Its receptors. This has resulted in the discovery of an enormous number of compounds of diverse structure that have DA receptor agonist and antagonist properties. 

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