Receptor Libraries

Krautwurst, D., Yau K.-W. and Reed R. R. (1998) Identification of ligands for olfactory receptors by functional expression of a receptor library. Cell 95, 917-926. 

The dansylated spacer alone does not bind to the receptor library, showing that the binding indeed occurs between the peptide part of the substrate and the receptor. 

The pioneering work in this area was reported by Lehn [80-83], both referring to ligand (imines) and to receptor libraries (barbiturate receptors and... 

Boyce R, Li G, Nestler HP, Suenaga T, Still W Clark, Peptidosteroidal receptors for opioid peptides. Sequence-selective binding using a synthetic receptor library, J. Am. Chem. Soc., 116 7955-7956, 1994. 

Figure 8.53 Dynamic combinatorial libraries receptor-driven ligand library selection (top) and ligand-driven receptor library selection (bottom).

Another example described in Section 9.5.3 reports the synthesis and screening of a synthetic receptor library aimed at transition metal binding. Other similar examples have been reported recently. Burger and Clark Still (211) prepared ionophoric, cyclen-based libraries decorated by amino acid units and screened them for their ability to complex copper and cobalt ions Malin et al. (212) identified novel hexapeptidic technetium-binding sequences from the screening of cellulose-bound libraries and... 

An Example Ligand and Receptor Libraries Based on Guanidinium Tweezer Receptors... 

Figure 9.51 Synthesis of the SP-encoded pool, guanidinium-based tweezer receptor library L36 and structure of the selection substrate 9.138.

Fig. 10.4 A screening strategy of a tailor-made RNP fluorescent sensor. Combination of the RNA subunit pool of the RNP receptor and Rev peptide subunits labeled with different fluorophores generates combinatorial fluorescent RNP receptor libraries, from which RNP sensors with desired optical and/or binding properties are screened...

De Miguel, Y. R., Sanders, J. K. M., Generation and screening of synthetic receptor libraries, Curr Opin ChemBiol 1998, 2, 417-421... 

Figure 36 A bile-acid-derived receptor library for opioid peptides [51]...

Guest-Selected Formation of Cages from a Dynamic Receptor Library. . 22... 

Thus, synthetic combinatorial receptor libraries of high diversity are a prerequisite for further progress in the field of chemosensors. As yet, there are no specific receptors available for most of the analytes, but this can be overcome by the use of sensor arrays. A mathematical analysis by pattern recognition can lead to a successful analysis of compound mixtures which are exposed to an array of sensors with different selectivities ( bio-electronic nose ) [13,14]. 

These few examples exhibit cavity-forming structures, making them suitable for receptor library developments. 

Goodman et al. [89] used metal ions as template for two-armed receptor libraries, and showed that octahedral Ru(II)-complexes with two terpyridine ligands could discriminate between two different ammonium derivatives. 

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