Synthetic receptors libraries

Boyce R, Li G, Nestler HP, Suenaga T, Still W Clark, Peptidosteroidal receptors for opioid peptides. Sequence-selective binding using a synthetic receptor library, J. Am. Chem. Soc., 116 7955-7956, 1994. 

Another example described in Section 9.5.3 reports the synthesis and screening of a synthetic receptor library aimed at transition metal binding. Other similar examples have been reported recently. Burger and Clark Still (211) prepared ionophoric, cyclen-based libraries decorated by amino acid units and screened them for their ability to complex copper and cobalt ions Malin et al. (212) identified novel hexapeptidic technetium-binding sequences from the screening of cellulose-bound libraries and... 

De Miguel, Y. R., Sanders, J. K. M., Generation and screening of synthetic receptor libraries, Curr Opin ChemBiol 1998, 2, 417-421... 

Boyce, R., Li, G., Nestler, H. P., Suenaga, T. and Still, W. C. (1994) Peptidosteroidal receptors for opioid peptides. Sequence-selective binding using a synthetic receptor library, J. Am. Chem. Soc. 116, 7955 Cheng, Y. A., Suenaga, T. and Still, W. C. (1996) Sequence-selective peptide binding with a peptido-A,B-trans-steroidal receptor selected from an encoded combinatorial receptor library, J. Am. Chem. Soc. 118, 1813-1814. 

Otto S, Severin K (2007) Dynamic Combinatorial Libraries for the Development of Synthetic Receptors and Sensors. 277 267-288... 

Still, W. C. Discovery of sequence-selective peptide binding by synthetic receptors using encoded combinatorial libraries. Acc. Chem. Res. 1996,29,155-163. 

Corbett, P. T Sanders, J. K. M. Otto, S. Exploring the relation between amplification and binding in dynamic combinatorial libraries of macrocyclic synthetic receptors in water. Chem. Eur. J. 2008,14, 2153-2166. 

The concept of tweezer-like two-armed molecules was used to construct synthetic receptor molecules based on methylene sulfonamide peptidomimetics.11291 When screened for binding against an encoded tripeptide library, one of the synthetic receptors demonstrated a remarkable binding selectivity 11291 the synthetic receptor affinity could be further increased by varying the hinge part of the peptidomimetic molecule.11301... 

After library synthesis and solid-phase assay of 100,000 beads on a red-labeled synthetic receptor [23], 55 deep staining beads were selected and their code was released via photolysis at 350 nM the released alcohols were silylated with N, O-bis(trimethylsilyl) acetamide and injected into a capillary GC with EC detection decoding 52 different structures, which are shown in Figure 9.7. 

A Borchardt, WC Still. Synthetic receptor binding elucidated with an encoded combinatorial library. J Am Chem Soc 116 373-374, 1994. 

---