Receptor INDEX

Wolfsberger S, DoostkamS, Boecher-Schwarz HG, et al. Progesterone-receptor index in meningiomas Correlation with clinico-pathological parameters and review of the literature. Neurosurg Rev. 2004 27 238-245. 

The development of ligands selective for individual receptor subtypes relevant to a targeted disease could decrease these toxic effects thereby improving the therapeutic index. Two new arotinoids are already available for topical use in skin diseases. These are tazarotenic acid (tazarotene) and 6-[3-(l-adamanty 1)-... 

Based just on these results, PPI could simply be just another index of DA function but phencyclidine, an NMDA rather than DA receptor antagonist, which exacerbates... 

The pathologic evaluation of breast lesions serves to establish the histologic diagnosis and to confirm the presence or absence of other factors believed to influence prognosis. These prognostic factors include the presence of necrosis, lymphatic or vascular invasion, nuclear grade, hormone receptor status, proliferative index, amount of aneuploidy, and HER-2/neu expression. 

Deeb SS, Fajas L, Nemoto M, Pihlaja-maki J, Mykkanen L, Kuusisto J et al. A Prol2Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nature Genet 1998 20[3] 284—287. 

Fig. 10.1 Binding event between analyte and receptor molecules occurring at the core cover interface of a three layer waveguide structure within the evanescent region of a guided mode. NeS indicates the effective refractive index of the fundamental guided mode...

The value of dn/dC depends on the properties of the material, e.g., in case of proteins this coefficient is 0.188 ml/g35 and in case of glucose dissolved in water (used for calibration measurements as discussed later in this chapter) this coefficient is 0.069 ml/g36. In the second mode of operation, analytes bind to the sensor surface (e.g., mediated by a receptor layer). In this case a thin layer with thickness w and refractive index nw is formed by the adsorbed analytes. Because the value of nw (e.g., 1.45 for proteins) is usually different than the refractive index of the solution (e.g., 1.33 for water) that contains the analyte molecules, a phase change is induced. The average layer growth (Aw) on the sensor surface can be related to the mass change (Am) per surface area (A) ... 

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