Real Time Storage

3 STABILITY OF DENDRIMER-ANTIBODYCONJUGATES 4.3.1 Real Time Storage 

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There may be other settings in the test method, such as timings for data collection, and these should normally be left at the default values. The time for the experiment should typically be set to 30 min. This is normally adequate, but if steady state occurs more quickly, it is not a problem, because most tests can be interrupted. The instrument should be set to display the following information in real time storage modulus (G ), loss modulus (G"), corrected phase angle (8), and the actual percent strain. If the instrument has the capability to display the waveforms visually, this should be switched on. 

In 2001, in a further round of discussions, it was proposed to change the real-time storage conditions for Zone IV from 30°C and 70% RH to 30°C and 65% RH. This suggestion was again circulated widely for comments and the results discussed in July 2001. 

Agrawal, S. Panchagnula, R. In vitro evaluation of fixed dose combination tablets of anti-tuberculosis drugs after real time storage at ambient conditions. Pharmazie 2004, 59 (10), 782-785. 

Real-time storage of 15 years at room temperature (27°C) has shown an impressive capacity loss less than 5%. 

A Real Time X-Ray Inspection System is introduced to replace Film X-Ray. The main objective is to reduce the consumption of film and to reduce the environmental pollution due to lead intensifying screens and chemicals. Other benefits are the reduction of space to storage X-ray data and the shorter inspection time, which gives a faster feed back to production. 

Real Time X-Ray images are stored on CD ROM/XA. Compared to film the volume for a storage is reduced by a factor 50. Retrieving is easy since information of the location is given in the directory of the diskette. Normally the directory name is the shop order and the file name is the serial number of the part. The directory and file names can be customised. 

Data to demonstrate the stability characteristics of both the drug substance and the drug product must be collected. Studies using three different batches of both substance and product in their respective containers/packaging must be conducted. Real-time data should be collected under conditions of temperature and relative humidity in line with the recommended storage. Conditions in different world climatic zones must be taken into consideration for cases where normal environmental... 

Storage conditions will be used. Standard conditions to simulate normal storage are temperatures of 25 or 30 °C and relative humidity of 60 or 65%. A minimum of 12 months real-time data is required for a marketing authorisation application. Real-time data should be supported by accelerated and intermediate stress testing at higher temperature/relative humidity. Photostability should be verified using a single batch. 

If we were to choose the ideal method for the analysis of any component of seawater, it would naturally be an in situ method. Where such a method is possible, the problems of sampling and sample handling are eliminated and in many cases we can obtain continuous profiles rather than limited number of discrete samples. In the absence of an in situ method, the next most acceptable alternative is analysis on board ship. A real-time analysis not only permits us to choose our next sampling station on the basis of the results of the last station, it also avoids the problem of the storage of samples until the return to a shore laboratory. 

The purpose of interfacing instruments with computers is to enable raw analytical data to be collected as it is produced, then processed, stored and displayed or printed out. This may be accomplished as it is gathered, i.e. in real-time, or at some later time, i.e. post-run. Complete chromatograms or spectra can easily be stored in the main memory or RAM or transferred to disk. The immense storage capacity of mainframe computers can be used to provide large libraries of data (data banks) for future reference. 

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