Reactive oxygen species 684 / INDEX

Colquhoun and Schumacher [98] have shown that y-linolcnic acid and eicosapentaenoic acid, which inhibit Walker tumor growth in vivo, decreased proliferation and apoptotic index in these cells. Development of apoptosis was characterized by the enhancement of the formation of reactive oxygen species and products of lipid peroxidation and was accompanied by a decrease in the activities of mitochondrial complexes I, III, and IV, and the release of cytochrome c and caspase 3-like activation of DNA fragmentation. Earlier, a similar apoptotic mechanism of antitumor activity has been shown for the flavonoid quercetin [99], Kamp et al. [100] suggested that the asbestos-induced apoptosis in alveolar epithelial cells was mediated by iron-derived oxygen species, although authors did not hypothesize about the nature of these species (hydroxyl radicals, hydrogen peroxide, or iron complexes ). 

The aim of the work was evaluation of the ability of photoexcited fullerene C60 and synthesized fullerene C60-containing composites to generate reactive oxygen species (ROS) and to perform comparative analysis of the state of the cells of two types (normal ones - thymocytes, and malignant ones - the cells of ascite Erhch carcinoma [EAC] and leucosis L1210) by such indexes as viability, content of LPO products, MTT test, and DNA fragmentation upon incubation in the presence of photoexcited fullerene C60. 

Reactive nitrogen species (RNS) and reactive oxygen species (ROS) can react with proteins leading to oxidatively modified proteins indexed by protein carbonyls and... 

Because of the high refractive index of ceria in the visible range (2.05 eV), ceria appears natural on the skin without imparting an excessively pale white look. Therefore, ceria is used as a UV-shielding material for cosmetics. However, the photocatalytic activity of ceria, which facilitates the generation of reactive oxygen species and has raised safety concerns, must be suppressed for such applications. ... 

Abbreviations IRP (iron responsive protein) ROS (reactive oxygen-derived active species) DP (developed pressure) EDP (end diastolic pressure) WI (cardiac work index) DHBA (dihydroxybenzoic acid) PC preconditioning CFF (coronary flow fraction). 

LeBel CP, Ali SF, McKee M, et al. 1990. Organometal-induced increases in oxygen reactive species The potential of 2, 7 -dichlorofluorescin diacetate as an index of neurotoxic damage. Toxicol Appl Pharmacol 104 17-34. 

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